PROTAC Linkers

PROTAC linkers are critical components in the architecture of PROTACs (Proteolysis Targeting Chimeras), serving as the connecting unit between the ligand that binds the target protein and the ligand that recruits an E3 ubiquitin ligase. The design of the linker is crucial for the efficacy of PROTACs, as its length, flexibility, and composition significantly influence the ability of the PROTAC to orient and position the target protein and E3 ligase for effective ubiquitination. Optimizing a linker's properties can enhance the stability, solubility, and overall bioavailability of PROTACs, thereby improving their therapeutic potential. Researchers continually experiment with different types of linkers to maximize the degradation of specific disease-related proteins.