Tos-PEG4-t-butyl ester

• CAT Number: I017554
• CAS Number: 217817-01-1
• Molecular Formula: C₂₀H₃₂O₈S
• Molecular Weight: 432.53
• Purity: ≥95%

Tos-PEG4-t-butyl ester (CAT: I017554) is a PEG-based PROTAC linker designed for use in the synthesis of PROTAC molecules. PROTACs (Proteolysis-Targeting Chimeras) are innovative compounds that can selectively degrade target proteins within cells by recruiting them to the cellular degradation machinery. The Tos-PEG4-Boc linker is used to conjugate the target protein-binding ligand and the E3 ligase ligand in a PROTAC molecule.

Reference

[1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.