Caspofungin and fungal infectionPublished on January 6, 2023 Inhibitors/Agonists
Caspofungin is a new type of echinocandin antifungal drug. As a prescription drug, it is mainly used to treat invasive candidiasis, invasive aspergillosis that is ineffective or intolerable to other treatments, and empirical treatment of suspected fungal infections in patients with neutropenia and fever. As a representative of a new class of echinocandins, caspofungin will become a research hotspot of systemic antifungal agents because of its obvious advantages of high selectivity, good antibacterial activity, high safety, less drug resistance and expiration of patent protection.
What is Policresulen and Used for?Published on January 5, 2023 Anti-infection
Policresulen is a drug against bacterial, fungal and protozoan infections. Policresulen has a broad spectrum of antibacterial activities, including gram-positive bacteria, gram-negative bacteria and certain fungi, notably against Canella, anaerobic bacteria and trichomoniasis. This product is used in organic synthesis, pharmaceutical research and development, and other scientific research fields.
What is Fluralaner？Published on December 28, 2022 agro
Fluralaner is a new broad-spectrum insecticide with isoxazoline structure, which is an effective inhibitor of ligand-gated chloride channels in neurons. Compared with other similar insecticides, it has significant differences in molecular structure, action site, selectivity, and cross-resistance. According to the relevant literature, as a broad-spectrum insecticide, Fluralaner has good insecticidal activity against most agricultural pests in addition to animal parasites, which can provide more choices for the prevention of sanitary pests and agricultural pests.
Tetramethylammonium Hydroxide (TMAH)Published on December 22, 2022 Catalysts
Tetramethylammonium Hydroxide (TMAH) is a colorless crystalline substance, often trihydrate (CAS: 10424-66-5) and pentahydrate (CAS: 10424-65-4), with a similar smell to certain amines. There is no trace residue even at low temperature treatment. It is very soluble in water and exothermic when dissolved, the aqueous solution is strongly alkaline and has a slippery feeling. Very easy to absorb moisture, in the air can quickly absorb carbon dioxide, 130 ℃ when the decomposition of methanol and trimethylamine, usually used with 10%, 25% water (or alcohol) solutions and compounds containing crystalline water.
Baloxavir Marboxil and InfluenzaPublished on December 22, 2022 Anti-infection
Influenza is an acute respiratory infectious disease caused by the influenza virus, which is mainly transmitted through droplets in the air, contact between susceptible people and infected people, or contact with contaminated items. It is usually a seasonal disease that breaks out once a year, killing thousands of people worldwide. Although rare, the mutation of the virus may cause human infection and spread rapidly, further leading to a pandemic (an infection that spreads worldwide) and causing millions of deaths.
Ursodeoxycholic Acid- A New Covid TreatmentPublished on December 14, 2022 inhibitors
Ursodeoxycholic acid(UDCA), chemical name 3α,7β-dihydroxy-5 β-cholestane-24-acid, is an odorless, organic compound(Scheme 1). In medicine, it is used to increase the secretion of bile acid, change the composition of bile, reduce cholesterol and cholesterol lipid in bile, and facilitate the gradual dissolution of cholesterol in gallstones. Clinically, it is used for the treatment of gallstones, cholestatic liver disease, fatty liver, various types of hepatitis, toxic liver disorders, cholecystitis, cholangitis and bile dyspepsia, bile reflux gastritis, eye diseases, etc.
Apoptosis Pathways and TargetsPublished on November 22, 2022 inhibitors
Apoptosis is a basic biological phenomenon of cells and plays a necessary role in the removal of unwanted or abnormal cells by multicellular organisms. It plays an important role in the evolution of organisms, the stability of the internal environment, and the development of multiple systems. Apoptosis is not only a special type of cell death but also has important biological significance and complex molecular biological mechanisms.
Monkeypox Prevention and TreatmentPublished on November 17, 2022 inhibitors
Monkeypox is a zoonotic infectious disease endemic in western and central Africa. caused by the monkeypox virus (MPXV), mainly manifested as fever, lymph node enlargement, rash, and so on.
Immune Checkpoint InhibitorsPublished on November 17, 2022 inhibitors
Immune checkpoints are molecules in the body’s immune system that protect against the overactivation of T cells, causing inflammatory damage, and so on. By taking advantage of this characteristic of the human immune system, tumor cells can inhibit the response of the human immune system by overexpressing immune checkpoint molecules, thus avoiding human immune surveillance and killing, thus promoting the growth of tumor cells. Immune checkpoint inhibitor therapy mainly inhibits the activity of the immune checkpoint and reactivates the immune response of T cells to tumor cells, thus achieving the anti-tumor effect, which makes it a new anti-tumor strategy.
Inhibitors VS Drug Discovery for Covid-19Published on November 2, 2022 COVID-19
In just 20 years, Coronaviruses have caused three pandemics of infectious diseases including COVID-19, severe cute respiratory syndrome coronavirus (SARS CoV), and Middle east respiratory syndrome coronavirus (MERS CoV). So far, there is no specific drug specifically for the prevention and treatment of coronavirus.