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Azide-PEG3-Tos

Azide-PEG3-Tos

  • CAT Number: I016810
  • CAS Number: 178685-33-1
  • Molecular Formula: C₁₃H₁₉N₃O₅S
  • Molecular Weight: 329.37
  • Purity: ≥95%
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Azide-PEG3-Tos (Cat No.:I016810) is a PROTAClinker, which belongs to the PEG class and can be used to synthesize PROTAC molecules. Azide-PEG3-Tos is also a non-cleavable ADClinker containing 3 units of PEG, which can be used to synthesize antibody-drug conjugates (ADCs).

Catalog Number I016810
CAS Number 178685-33-1
Molecular Formula

C₁₃H₁₉N₃O₅S

Purity 95%
IUPAC Name 2-[2-(2-azidoethoxy)ethoxy]ethyl 4-methylbenzenesulfonate
InChI InChI=1S/C13H19N3O5S/c1-12-2-4-13(5-3-12)22(17,18)21-11-10-20-9-8-19-7-6-15-16-14/h2-5H,6-11H2,1H3
InChIKey PTOJCKLTCKYNFG-UHFFFAOYSA-N
SMILES CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCN=[N+]=[N-]
Reference

[1]. Borchmann DE, et al. GRGDS-Functionalized Poly(lactide)-graft-poly(ethylene glycol) Copolymers: Combining Thiol-Ene Chemistry with Staudinger Ligation. Macromolecules. 2013 Jun 11;46(11):4426-4431.<br>[2]. Park, Tae Kyo, et al. Compound bearing beta-galactoside-introduced self-immolative linker. WO2018124758A2.

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