Propargyl-PEG5-OH

• CAT Number: I017047
• CAS Number: 1036204-60-0
• Molecular Formula: C₁₃H₂₄O₆
• Molecular Weight: 276.33
• Purity: ≥95%

Propargyl-PEG5-OH (CAT: I017047) is a PEG-based PROTAC linker that plays a crucial role in the synthesis of PROTAC molecules. PROTACs (PROteolysis TArgeting Chimeras) are innovative compounds designed to harness the ubiquitin-proteasome system for targeted protein degradation. The presence of the propargyl group in Propargyl-PEG5-OH provides a reactive handle for conjugation to other molecular components within a PROTAC structure. This linker contributes to the overall structure of PROTACs, enabling the specific binding of the PROTAC to its target protein, followed by its degradation by the cellular machinery.

Reference

[1]. Robert Zamboni, et al. Raf-degrading conjugate compounds. WO2018200981A1.