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Tos-PEG4-THP

Tos-PEG4-THP

  • CAT Number: I016933
  • CAS Number: 86259-89-4
  • Molecular Formula: C₂₀H₃₂O₈S
  • Molecular Weight: 432.53
  • Purity: ≥95%
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Tos-PEG4-THP(CAT: I016933) is a crucial PEG-based linker utilized in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523). This linker plays a pivotal role in connecting the target-binding ligand with the E3 ligase ligand within the PROTAC molecule. The polyethylene glycol (PEG) spacer enhances solubility, biocompatibility, and flexibility, enabling efficient intracellular delivery and engagement of the cellular degradation machinery.

Catalog Number I016933
CAS Number 86259-89-4
Molecular Formula

C₂₀H₃₂O₈S

Purity 95%
Reference

[1]. Andrew P. Crew, et al. Modulators of proteolysis and associated methods of use. WO2019195609A2.

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