dBET57

• CAT Number: I019018
• CAS Number: 1883863-52-2
• Molecular Formula: C₃₄H₃₁ClN₈O₅S
• Molecular Weight: 699.18
• Purity: ≥95%

dBET57(CAT: I019018) stands as a potent and selective degrader of BRD4BD1, harnessed through the innovative PROTAC technology. This compound orchestrates the recruitment of BRD4BD1 to the CRL4CRBN E3 ubiquitin ligase, displaying a DC50/5h of 500 nM for BRD4BD1 and remaining inactive on BRD4BD2[1]. By exploiting these mechanisms, dBET57 offers a targeted approach to protein degradation, where specific components within the cellular machinery are harnessed to selectively eliminate proteins of interest. This compound showcases the potential of PROTAC technology in drug discovery, particularly in influencing protein functions through degradation pathways.

Reference

[1]. Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14(7):706-714.