Azido-PEG9-acid

• CAT Number: I016989
• CAS Number: 1670249-37-2
• Molecular Formula: C₂₁H₄₁N₃O₁₁
• Molecular Weight: 511.56
• Purity: ≥95%
• IUPAC Name: 3-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C21H41N3O11/c22-24-23-2-4-28-6-8-30-10-12-32-14-16-34-18-20-35-19-17-33-15-13-31-11-9-29-7-5-27-3-1-21(25)26/h1-20H2,(H,25,26)
• InChIKey: SITPDBHRMHFFHS-UHFFFAOYSA-N
• SMILES: C(COCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(=O)O

Azido-PEG9-acid（Cat No.:I016989） is a non-cleavable linker used for the synthesis of antibody-drug conjugates (ADCs) and PROTAC molecules. It consists of 9 units of polyethylene glycol (PEG) and contains an azido group. As an ADC linker, it enables the attachment of drugs to antibodies, allowing targeted delivery of therapeutic agents to specific cells. As a PROTAC linker, it facilitates the connection of target protein binders with degradation tags, enabling the design of bifunctional molecules for targeted protein degradation. The presence of the PEG chain enhances solubility and biocompatibility.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.