Propargyl-PEG4-Tos

• CAT Number: I017011
• CAS Number: 875770-32-4
• Molecular Formula: C₁₈H₂₆O₇S
• Molecular Weight: 386.46
• Purity: ≥95%

Propargyl-PEG4-Tos(CAT: I017011), also known as propargyl tetraethylene glycol tosylate, is a compound commonly used in chemical synthesis and bioconjugation applications. It is a derivative of tetraethylene glycol with a propargyl (alkyne) functional group and a tosylate leaving group. The propargyl group enables click chemistry reactions, specifically the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), which is widely used for bioconjugation and labeling of biomolecules. Propargyl-PEG4-Tos is often employed for the modification of proteins, peptides, oligonucleotides, and other molecules to introduce specific functionalities or enable further conjugation reactions.

Reference

[1]. Wurz RP, et al. A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing ProteinDegradation. J Med Chem. 2018 Jan 25;61(2):453-461.[2]. Senthilkumar T, et al. Conjugated Polymer Nanoparticles with Appended Photo-Responsive Units for Controlled DrugDelivery, Release, and Imaging. Angew Chem Int Ed Engl. 2018 Oct 1;57(40):13114-13119.