ROCK

Rho-associated protein kinase (ROCK) is a serine/threonine kinase that plays a pivotal role in various cellular functions, including contraction, motility, proliferation, and apoptosis. ROCK is activated by the small GTPase Rho and is involved in reorganizing the actin cytoskeleton, a key process in cell shape and movement. There are two isoforms, ROCK1 and ROCK2, which share considerable similarities but are distributed differently in tissues and have distinct functions. Due to its significant role in regulating smooth muscle contraction and cell migration, ROCK is a therapeutic target for diseases such as hypertension, asthma, and cancer. Inhibiting ROCK activity has shown potential in treating conditions linked to abnormal cellular contraction and migration.