Thiazovivin

• CAT Number: I000870
• CAS Number: 1226056-71-8
• Molecular Formula: C₁₅H₁₃N₅OS
• Molecular Weight: 311.36
• Purity: ≥95%
• Target: ROCK
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IC50: 0.5 μM
• IUPAC Name: N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide
• InChI: InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)
• InChIKey: DOBKQCZBPPCLEG-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3

Thiazovivin (Cat No.: I000870) is a novel ROCK (Rho-associated protein kinase) inhibitor characterized by its low IC50 of 0.5 μM. This compound is particularly noteworthy for its ability to enhance the survival of human embryonic stem cells (hESC) following single-cell isolation, making it a valuable tool in stem cell research and regenerative medicine. If you need to, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

1:[Effect of a new ROCK inhibitor thiazovivin on the morphology and function of human corneal endothelial cells]. Wu QN, Ling YZ, Ouyang C, Xie LJ, Huang T.Zhonghua Yan Ke Za Zhi. 2016 Sep 11;52(9):686-92. doi: 10.3760/cma.j.issn.0412-4081.2016.09.010. Chinese. PMID: 27647250 2:Thiazovivin, a Rho kinase inhibitor, improves stemness maintenance of embryo-derived stem-like cells under chemically defined culture conditions in cattle. Park S, Kim D, Jung YG, Roh S.Anim Reprod Sci. 2015 Oct;161:47-57. doi: 10.1016/j.anireprosci.2015.08.003. Epub 2015 Aug 15. PMID: 26307658 3:Reprogramming of endometrial adult stromal cells in the presence of a ROCK inhibitor, thiazovivin, could obtain more efficient iPSCs. Mohseni R, Shoae-Hassani A, Verdi J.Cell Biol Int. 2015 May;39(5):515-8. doi: 10.1002/cbin.10411. Epub 2015 Mar 15. PMID: 25490878