GSK-25

• CAT Number: I017522
• CAS Number: 874119-56-9
• Molecular Formula: C₂₄H₁₆Cl₂F₂N₆O
• Molecular Weight: 513.33
• Purity: ≥95%

GSK-25(CAT: I017522) is a significant compound recognized for its potency, selectivity, and oral bioavailability as a ROCK1 (Rho-associated protein kinase 1) inhibitor. Through its targeted inhibition of ROCK1, GSK-25 holds promise in regulating cellular processes influenced by ROCK1-mediated signaling pathways. This inhibitor’s specific action on ROCK1 underscores its potential applicability in various contexts, such as modulating cell morphology, cytoskeletal dynamics, and other ROCK1-associated functions.

Reference

[1]. Sehon CA, et al. Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases. J Med Chem. 2008 Nov 13;51(21):6631-4.