• CAT Number: I001786
  • CAS Number: 146986-50-7
  • Molecular Formula: C₁₄H₂₁N₃O.2HCl
  • Molecular Weight: 320.26
  • Purity: ≥95%
Inquiry Now

Y-27632 (Cat No.:I001786) is an orally active, ATP-competitive ROCK-I and ROCK-II inhibitor with Ki of 220nM and 300nM, respectively. Y-27632 induces apoptosis. Y-27632 induces selective differentiation of human induced pluripotent stem cells (hIPSCs) into the mesendermal lineage through epithelial-mesenchymal transition-like regulation.

Catalog Number I001786
CAS Number 146986-50-7


Molecular Formula


Purity 95%
Target ROCK
Solubility DMSO: ≥ 32 mg/mL
Storage Store at -20C
Related CAS 129830-38-2(hydrochloride)
IC50 140 nM (Ki)
InChI InChI=1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11?,12?;;/m1../s1

<br />
[1]. Uehata M, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature, 1997, 389(6654), 990-994.<br />
[2]. Inan, S. Y.; Bueyuekafsar, K. Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice. British Journal of Pharmacology (2008), 155(1), 44-51.<br />
[3]. Xue ZW, et al. Rho-associated coiled kinase inhibitor Y-27632 promotes neuronal-like differentiation of adult human adipose tissue-derived stem cells.Chin Med J (Engl). 2012 Sep;125(18):3332-5.<br />
[4]. Sharma R, et al. ROCK inhibitor Y-27632 enhances the survivability of dissociated buffalo (Bubalus bubalis) embryonic stem cell-like cells.Reprod Fertil Dev. 2012 May 3.<br />
[5]. Lemeshchenko VV, et al. [Y-27632 induces calcium-independent glutamate release in rat brain synaptosomes by the mechanism which is distinct from exocytosis].Biofizika. 2012 May-Jun;57(3):454-9.</p>

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!