Y-27632

• CAT Number: I001786
• CAS Number: 146986-50-7
• Molecular Formula: C₁₄H₂₁N₃O.2HCl
• Molecular Weight: 320.26
• Purity: ≥95%
• Synonyms: 4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide
• Target: ROCK
• Solubility: DMSO: ≥ 32 mg/mL
• Storage: Store at -20C
• Related CAS: 129830-38-2(hydrochloride)
• IC50: 140 nM (Ki)
• InChI: InChI=1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11?,12?;;/m1../s1
• InChIKey: IDDDVXIUIXWAGJ-DDSAHXNVSA-N
• SMILES: CC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl

Y-27632 (Cat No.:I001786) is an orally active, ATP-competitive ROCK-I and ROCK-II inhibitor with Ki of 220nM and 300nM, respectively. Y-27632 induces apoptosis. Y-27632 induces selective differentiation of human induced pluripotent stem cells (hIPSCs) into the mesendermal lineage through epithelial-mesenchymal transition-like regulation.

Reference

[1]. Uehata M, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature, 1997, 389(6654), 990-994.
[2]. Inan, S. Y.; Bueyuekafsar, K. Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice. British Journal of Pharmacology (2008), 155(1), 44-51.
[3]. Xue ZW, et al. Rho-associated coiled kinase inhibitor Y-27632 promotes neuronal-like differentiation of adult human adipose tissue-derived stem cells.Chin Med J (Engl). 2012 Sep;125(18):3332-5.
[4]. Sharma R, et al. ROCK inhibitor Y-27632 enhances the survivability of dissociated buffalo (Bubalus bubalis) embryonic stem cell-like cells.Reprod Fertil Dev. 2012 May 3.
[5]. Lemeshchenko VV, et al. [Y-27632 induces calcium-independent glutamate release in rat brain synaptosomes by the mechanism which is distinct from exocytosis].Biofizika. 2012 May-Jun;57(3):454-9.