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H-1152 Glycyl Dihydrochloride

H-1152 Glycyl Dihydrochloride

  • CAT Number: R009434
  • CAS Number: 913844-45-8
  • Molecular Formula: C18H24N4O3S • 2HCl
  • Molecular Weight: 449.4
  • Purity: ≥95%
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Two Rho-associated kinases (ROCK), ROCK-<wbr></wbr>I and ROCK-<wbr></wbr>II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. Glycyl-<wbr></wbr>H-<wbr></wbr>1152 is a selective and potent ROCK inhibitor (IC<sub>50</sub> = 11.8 nM for ROCK-<wbr></wbr>II). It is a glycylated isoquinoline compound derived from the therapeutically-<wbr></wbr>important ROCK inhibitor HA-<wbr></wbr>1077 (Fasudil) and exhibits better specificity. Thus, it poorly inhibits Ca

Catalog Number R009434
CAS Number 913844-45-8
Synonyms

2-Amino-1-[(3S)-hexahydro-3-methyl-4-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepin-1-yl]ethanone Hydrochloride; (2S)-4-(Aminoacetyl)hexahydro?-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepine Dihydrochloride;

Molecular Formula

C18H24N4O3S • 2HCl

Purity 95%
Storage -20°C
InChIKey CMKMGFAUKPAOMG-AWEZNQCLSA-N

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