Fasudil hydrochloride hydrate

• CAT Number: I027289
• CAS Number: 186694-02-0
• Molecular Formula: C28H38Cl2N6O5S2
• Molecular Weight: 673.67
• Purity: 98%
• Solubility: Soluble in DMSO
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-, monohydrochloride, hydrate (2:1)
• InChI: InChI=1S/2C14H17N3O2S.2ClH.H2O/c2*18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;;/h2*1,3-5,7,11,15H,2,6,8-10H2;2*1H;1H2
• InChIKey: AACOJGPCMIDLEY-UHFFFAOYSA-N
• SMILES: O.Cl.Cl.O=S(=O)(N1CCCNCC1)c2cccc3cnccc23.O=S(=O)(N4CCCNCC4)c5cccc6cnccc56

Fasudil hydrochloride hydrate (CAT: I027289) is the hydrochloride salt form of Fasudil, which is a potent inhibitor of Rho-kinase (ROCK). ROCK is an enzyme that plays a role in various cellular processes, including smooth muscle contraction, cell migration, and vascular remodeling. Fasudil hydrochloride has demonstrated efficacy in hindering the development of mature lesions in Cerebral Cavernous Malformation (CCM), a vascular disorder, and it has also shown the ability to reduce portal venous pressure in cirrhotic rats.

Reference

1. Shenkar R, Shi C, Austin C, Moore T, Lightle R, Cao Y, Zhang L, Wu M, Zeineddine HA, Girard R, McDonald DA, Rorrer A, Gallione C, Pytel P, Liao JK, Marchuk DA, Awad IA. RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations. Stroke. 2017 Jan;48(1):187-194. doi: 10.1161/STROKEAHA.116.015013. Epub 2016 Nov 22. PMID: 27879448; PMCID: PMC5183488.
2. McDonald DA, Shi C, Shenkar R, Stockton RA, Liu F, Ginsberg MH, Marchuk DA, Awad IA. Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. Stroke. 2012 Feb;43(2):571-4. doi: 10.1161/STROKEAHA.111.625467. Epub 2011 Oct 27. PMID: 22034008; PMCID: PMC3265629.
3. Fukuda T, Narahara Y, Kanazawa H, Matsushita Y, Kidokoro H, Itokawa N, Kondo C, Atsukawa M, Nakatsuka K, Sakamoto C. Effects of fasudil on the portal and systemic hemodynamics of patients with cirrhosis. J Gastroenterol Hepatol. 2014 Feb;29(2):325-9. doi: 10.1111/jgh.12360. PubMed PMID: 24033356.