Glucocorticoid Receptor

The glucocorticoid receptor (GR) is a type of nuclear receptor that binds glucocorticoids, a class of steroid hormones. This receptor plays a key role in regulating genes controlling development, metabolism, and immune response. Upon binding its ligand, the GR translocates from the cytoplasm to the nucleus, where it can act as a transcription factor to either activate or repress specific genes. Its actions are crucial for stress response, inflammation reduction, and maintaining energy balance. Dysregulation of GR function is associated with various conditions, including inflammatory diseases, metabolic disorders, and psychiatric issues. Therefore, GR is a significant target in the development of anti-inflammatory and immunosuppressant therapies.