| Catalog Number | I000634 |
| CAS Number | 1177-87-3 |
| Molecular Formula | C24H31FO6
|
| Purity | 95% |
| Target | Glucocorticoid Receptor |
| Solubility | DMSO: ≥ 29 mg/mL |
| Storage | 3 years -20℃ powder |
| Overview of Clinical Research | <span style=”color:#000000;”><span style=”font-size:12px;”><span style=”caret-color: rgb(0, 0, 0); font-family: arial, helvetica, sans-serif;”>Dexamethasone </span><span style=”font-family: arial, helvetica, sans-serif; caret-color: rgb(33, 33, 33); orphans: 2; widows: 2;”>acetate is a </span><span style=”font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; orphans: 2; widows: 2;”>glucocorticoid receptor agonist. The </span><span style=”font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;”>Phase-I/II clinical trials in Back pain in Australia (Epidural) (NCT03952377) started in 2019.</span></span></span>
|
| IC50 | 58 nM (HECM-induced eosinophil survival) |
| IUPAC Name | [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate |
| InChI | InChI=1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17+,18+,19+,21+,22+,23+,24+/m1/s1 |
| InChIKey | AKUJBENLRBOFTD-RPRRAYFGSA-N |
| SMILES | CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C)O)C)O)F)C |
| Reference | <p style=”/line-height:25px/”>
<br />
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[2]. Leskiewicz M, Jantas D, Regulska M, Antidepressants attenuate the dexamethasone-induced decrease in viability and proliferation of human neuroblastoma SH-SY5Y cells: A involvement of extracellular regulated kinase (ERK1/2). Neurochem Int. 2013 Jul 29. pii: S0197-0186(13)00202-7.<br />
[3]. Heberden C, Meffray E, Goustard-Langelier B, Dexamethasone inhibits the maturation of newly formed neurons and glia supplemented with polyunsaturated fatty acids. J Steroid Biochem Mol Biol. 2013 Jul 29. pii: S0960-0760(13)00139-8.<br />
[4]. Lu XX, McCoy KS, Hu WK, Dexamethasone reduces IL-17 and Tim-3 expression in BALF of asthmatic mice. J Huazhong Univ Sci Technolog Med Sci. 2013 Aug;33(4):479-84.<br />
[5]. Wyns H, Meyer E, Watteyn A, Pharmacokinetics of dexamethasone after intravenous and intramuscular administration in pigs. Vet J. 2013 Jul 19. pii: S1090-0233(13)00299-2.</p>
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