CONTACT US
Home > Inhibitors/Agonists>Glucocorticoid Receptor> > Betamethasone
Betamethasone

Betamethasone

  • CAT Number: A001143
  • CAS Number: 378-44-9
  • Molecular Formula: C22H29FO5
  • Molecular Weight: 392.5
  • Purity: ≥95%
Inquiry Now

Betamethasone (CAS 378-44-9) is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, betamethasone does not cause water retention. It is applied as a topical cream, ointment, foam, lotion or gel to treat itching. Betamethasone sodium phosphate is sometimes prescribed as an intramuscular injection (I.M) for itching from various ailments including allergic reactions to poison ivy and similar plants.

Catalog Number A001143
CAS Number 378-44-9
Molecular Formula

C22H29FO5

Purity 95%
Target Glucocorticoid Receptor
Solubility >19.6mg/mL in DMSO
Storage 3 years -20C powder
Overview of Clinical Research

<span style="color:#000000;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">Betamethasone is a g<span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">lucocorticoid receptor agonist. It is under the preclinical study in&nbsp;</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">Meniere&#39;s disease.</span></span></span></span>

IUPAC Name (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1
InChIKey UREBDLICKHMUKA-DVTGEIKXSA-N
SMILES CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
Reference

<br />
1:Efficacy of Topical Latanoprost Versus Minoxidil and Betamethasone Valerate on The Treatment of Alopecia Areata. El-Ashmawy AA, El-Maadawy IH, El-Maghraby GM.J Dermatolog Treat. 2017 May 18:1-31. doi: 10.1080/09546634.2017.1330527. [Epub ahead of print] PMID: 28521549<br />
2:A Comparison of Betamethasone Valerate 0.1% Cream Twice Daily Plus Oral Simvastatin Versus Betamethasone Valerate 0.1% Cream Alone in the Treatment of Vitiligo Patients. Iraji F, Banihashemi SH, Faghihi G, Shahmoradi Z, Tajmirriahi N, Jazi SB.Adv Biomed Res. 2017 Mar 28;6:34. doi: 10.4103/2277-9175.203159. eCollection 2017. PMID: 28516068<br />
3:Betamethasone causes intergenerational reproductive impairment in male rats. Borges CDS, Pacheco TL, da Silva KP, Fernandes FH, Gregory M, Pupo AS, Salvadori DMF, Cyr DG, Kempinas WG.Reprod Toxicol. 2017 May 10;71:108-117. doi: 10.1016/j.reprotox.2017.04.012. [Epub ahead of print] PMID: 28501545<br />
4:Acid-Sensitive Sheddable PEGylated, Mannose-Modified Nanoparticles Increase the Delivery of Betamethasone to Chronic Inflammation Sites in a Mouse Model. O/&#39;Mary HL, Aldayel AM, Valdes SA, Naguib YW, Li X, Salvady K, Cui Z.Mol Pharm. 2017 May 10. doi: 10.1021/acs.molpharmaceut.7b00024. [Epub ahead of print] PMID: 28463518<br />
5:Penetration Route of the Selective Glucocorticoid Receptor Agonist SA22465 and Betamethasone into Rabbit Meibomian Gland Based on Pharmacokinetics and Autoradiography. Asano N, Ueda K, Kawazu K.Drug Metab Dispos. 2017 Apr 24. pii: dmd.117.075473. doi: 10.1124/dmd.117.075473. [Epub ahead of print] PMID: 28438780<br />
6:Antenatal betamethasone for women at risk for late preterm delivery reduces the rate of neonatal respiratory complications. Canty HR, Dukhovny S, Warren JB.Acta Paediatr. 2017 Apr 18. doi: 10.1111/apa.13825. [Epub ahead of print] No abstract available. PMID: 28419555<br />
7:Longitudinal progression of fetal short-term variation and average acceleration and deceleration capacity after antenatal maternal betamethasone application. Weyrich J, Setter A, M&uuml;ller A, Schmidt G, Brambs CE, Ortiz JU, Lobmaier SM.Eur J Obstet Gynecol Reprod Biol. 2017 May;212:85-90. doi: 10.1016/j.ejogrb.2017.03.025. Epub 2017 Mar 18. PMID: 28342395<br />
8:Reproductive disorders in female rats after prenatal exposure to betamethasone. Borges CS, Pacheco TL, Guerra MT, Barros AL, Silva PV, Missassi G, da Silva KP, Anselmo-Franci JA, Pupo AS, Kempinas WG.J Appl Toxicol. 2017 Mar 21. doi: 10.1002/jat.3457. [Epub ahead of print] PMID: 28326570<br />
9:A Topical Treatment Optimisation Programme (TTOP) improves clinical outcome to calcipotriol/betamethasone gel in psoriasis: Results of the 64-week, multinational, randomized, phase IV study in 1790 patients (PSO-TOP). Reich K, Zschocke I, Bachelez H, de Jong EM, Gisondi P, Puig L, Warren RB, Ortland C, Mrowietz U; PSO-TOP study group..Br J Dermatol. 2017 Mar 16. doi: 10.1111/bjd.15466. [Epub ahead of print] PMID: 28301043<br />
10:Impact of a terbinafine-florfenicol-betamethasone acetate otic gel on the quality of life of dogs with acute otitis externa and their owners. Noli C, Sartori R, Cena T.Vet Dermatol. 2017 Mar 15. doi: 10.1111/vde.12433. [Epub ahead of print] PMID: 28295766

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!