Fluticasone propionate

• CAT Number: A000952
• CAS Number: 80474-14-2
• Molecular Formula: C25H31F3O5S
• Molecular Weight: 500.6
• Purity: ≥95%
• Target: Glucocorticoid Receptor
• Solubility: >18.5mg/mL in DMSO
• Storage: -20°C
• InChI: 1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1
• InChIKey: WMWTYOKRWGGJOA-JUHDKXAESA-N
• SMILES: CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF

Fluticasone propionate belongs to a class of drugs known as corticosteroids, specifically glucocorticoids, which are hormones that predominantly affect the metabolism of carbohydrates and, to a lesser extent, fat and protein. It is used to treat asthma, allergic rhinitis, nasal polyps, various skin disorders and Crohn/’s disease and ulcerative colitis. It is also used to treat eosinophilic esophagitis.

Reference

1: Sohal SS. Fluticasone propionate and increased risk of pneumonia in COPD: is
it PAFR-dependent? Int J Chron Obstruct Pulmon Dis. 2017 Dec 4;12:3425-3427. doi:
10.2147/COPD.S154897. eCollection 2017. PubMed PMID: 29271974; PubMed Central
PMCID: PMC5720348.

2: Weiler JM, Sorkness CA, Hendeles L, Nichols S, Zhu Y. Randomized,
Double-Blind, Crossover, Clinical-End-Point Pilot Study to Examine the Use of
Exhaled Nitric Oxide as a Bioassay for Dose Separation of Inhaled Fluticasone
Propionate. J Clin Pharmacol. 2017 Nov 28. doi: 10.1002/jcph.1043. [Epub ahead of
print] PubMed PMID: 29193247.

3: Liu L, Ong G. A randomized, open-label study to evaluate an intermittent
dosing regimen of fluticasone propionate 0.05% cream in combination with regular
emollient skin care in reducing the risk of relapse in pediatric patients with
stabilized atopic dermatitis. J Dermatolog Treat. 2017 Nov 22:1-9. doi:
10.1080/09546634.2017.1401211. [Epub ahead of print] PubMed PMID: 29164960.

4: Al-Maqbali A, Kamble B, Al-Qassabi S, Elgalib A. Secondary Adrenal
Insufficiency Due to the Co-Administration of Ritonavir and Inhaled Fluticasone
Propionate: Case report. Sultan Qaboos Univ Med J. 2017 Aug;17(3):e339-e342. doi:
10.18295/squmj.2017.17.03.014. Epub 2017 Oct 10. PubMed PMID: 29062559; PubMed
Central PMCID: PMC5642366.

5: Bernstein D, Andersen L, Forth R, Jacques L, Yates L. Once-daily fluticasone
furoate/vilanterol versus twice-daily fluticasone propionate/salmeterol in
patients with asthma well controlled on ICS/LABA. J Asthma. 2017 Sep 29:0. doi:
10.1080/02770903.2017.1386214. [Epub ahead of print] PubMed PMID: 28961020.

6: Nugent C, Yiu G, Song S, Caracta C. The pharmacokinetics, safety, and
tolerability of single, high-strength doses of fluticasone propionate and
fluticasone propionate/salmeterol delivered via a novel multidose dry powder
inhaler in adolescents and adults with persistent asthma. J Asthma. 2017 Sep
21:1-9. doi: 10.1080/02770903.2017.1373392. [Epub ahead of print] PubMed PMID:
28933971.

7: Ishiura Y, Fujimura M, Shiba Y, Ohkura N, Hara J, Abo M, Kasahara K. A
Comparison of the Efficacy of Once-Daily Fluticasone Furoate/Vilanterole with
Twice-Daily Fluticasone Propionate/Salmeterol in Elderly Asthmatics. Drug Res
(Stuttg). 2018 Jan;68(1):38-44. doi: 10.1055/s-0043-118536. Epub 2017 Sep 19.
PubMed PMID: 28926855.

8: Jetzer MW, Morrical BD, Fergenson DP, Imanidis G. Particle interactions of
fluticasone propionate and salmeterol xinafoate detected with single particle
aerosol mass spectrometry (SPAMS). Int J Pharm. 2017 Oct 30;532(1):218-228. doi:
10.1016/j.ijpharm.2017.08.113. Epub 2017 Aug 31. PubMed PMID: 28864391.

9: Craparo EF, Ferraro M, Pace E, Bondì ML, Giammona G, Cavallaro G.
Polyaspartamide-Based Nanoparticles Loaded with Fluticasone Propionate and the In
Vitro Evaluation towards Cigarette Smoke Effects. Nanomaterials (Basel). 2017 Aug
13;7(8). pii: E222. doi: 10.3390/nano7080222. PubMed PMID: 28805713; PubMed
Central PMCID: PMC5575704.

10: Getgood A, Dhollander A, Malone A, Price J, Helliwell J. Pharmacokinetic
Profile of Intra-articular Fluticasone Propionate Microparticles in Beagle Dog
Knees. Cartilage. 2017 Aug 1:1947603517723687. doi: 10.1177/1947603517723687.
[Epub ahead of print] PubMed PMID: 28786292.