Amyloid-β
Amyloid-β (Aβ) is a peptide implicated primarily in the pathogenesis of Alzheimer’s disease. It is derived from the cleavage of the amyloid precursor protein (APP) by enzymes called secretases. Aβ peptides can aggregate to form fibrils and plaques, which are hallmark features of Alzheimer’s disease observed in the brains of affected individuals. These plaques disrupt cell function and trigger inflammatory responses, leading to neuronal damage and loss, which manifest as cognitive decline and memory loss. Due to its central role in Alzheimer’s pathology, Aβ is a major target for therapeutic intervention, with treatments aiming to reduce its production, enhance its clearance, or prevent its aggregation.