AAK1
AP2-associated kinase 1 (AAK1) is a serine/threonine kinase that plays a crucial role in regulating clathrin-mediated endocytosis, the process by which cells internalize molecules such as nutrients, hormones, and neurotransmitters. AAK1 modulates this pathway by phosphorylating the μ2 subunit of the AP2 adaptor complex, enhancing clathrin binding and promoting vesicle formation. Given its pivotal role in cellular trafficking, AAK1 is linked to several neurological disorders and viral infections. As such, it is considered a potential therapeutic target. Inhibiting AAK1 activity could disrupt viral entry and replication, offering a novel approach for antiviral treatments, as well as managing diseases influenced by altered cellular trafficking.