γ-secretase
γ-secretase is a complex, intramembrane-cleaving protease that plays a crucial role in processing several proteins, including the amyloid precursor protein (APP) and Notch. When it cleaves APP, γ-secretase facilitates the production of amyloid-beta (Aβ) peptides, central to the formation of amyloid plaques in Alzheimer’s disease. Its activity on Notch signaling is also vital for cell differentiation and development. Due to its dual roles in Alzheimer’s pathology and cellular development, γ-secretase has become a significant therapeutic target. Inhibiting γ-secretase can potentially reduce Aβ levels and mitigate Alzheimer’s progression. However, its inhibition must be carefully managed to avoid disrupting essential Notch-related processes in healthy cells.