COMT
Catechol-O-methyltransferase (COMT) is an enzyme that plays a critical role in the metabolism of catecholamines, such as dopamine, epinephrine, and norepinephrine. By transferring a methyl group from S-adenosylmethionine to catechols, COMT helps regulate neurotransmitter levels in the brain and peripheral tissues, influencing mood, cognition, and bodily responses to stress. The enzyme exists in two forms: a soluble form (S-COMT) and a membrane-bound form (MB-COMT), with varying distributions throughout the body. COMT activity varies among individuals due to genetic variations, affecting susceptibility to psychiatric disorders, pain sensitivity, and response to medications. COMT inhibitors are explored for potential therapeutic benefits in conditions like Parkinson’s disease and schizophrenia.