Tranexamic Acid

• CAT Number: A001144
• CAS Number: 1197-18-8
• Purity: ≥95%
• Storage: 3 years -20C powder

Carbamic acid (Cat No.: A001144), also known as tranexamic acid, is chemically named 4-aminomethyl cyclohexane carboxylic acid, and its trade name is dopamine. Tranexamic acid is an artificial lysine analog, which can competitively bind the lysine binding site on plasminogen and plasmin, thereby competitively inhibiting the degradation of fibrin, reducing fibrinolytic activity and playing a role in promoting blood coagulation. It is mainly used for hemostatic drugs, with a significant effect on traumatic bleeding. Preoperative preventive drugs can reduce surgical bleeding.

Reference

1:Correction of Severe Coagulopathy and Hyperfibrinolysis by Tranexamic Acid and Recombinant Factor VIIa in a Cirrhotic Patient After Trauma: A Case Report. Louro J, Andersen K, Dudaryk R.A A Case Rep. 2017 May 12. doi: 10.1213/XAA.0000000000000550. [Epub ahead of print] PMID: 28509781 2:Comparison of intra-articular versus intravenous application of tranexamic acid in total knee arthroplasty: a meta-analysis of randomized controlled trials. Liu Y, Meng F, Yang G, Kong L, Shen Y.Arch Med Sci. 2017 Apr 1;13(3):533-540. doi: 10.5114/aoms.2017.67278. Epub 2017 Apr 20. Review. PMID: 28507566 Free PMC Article3:Tranexamic Acid Effectively Reduces Blood Loss and Transfusion Rates during Simultaneous Bilateral Total Knee Arthroplasty. Prieto HA, Vincent HK, Deen JT, Iams DA, Parvataneni HK.J Knee Surg. 2017 May 15. doi: 10.1055/s-0037-1603333. [Epub ahead of print] No abstract available. PMID: 28505683 4:Does Tranexamic Acid Reduce Bleeding during Femoral Fracture Operation? Haghighi M, Ettehad H, Mardani-Kivi M, Mirbolook A, Nabi BN, Moghaddam R, Sedighinejad A, Khanjanian G.Arch Bone Jt Surg. 2017 Mar;5(2):103-108. PMID: 28497100 Free PMC Article5:Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery. Wang DS, Mazer CD, Orser BA.N Engl J Med. 2017 May 11;376(19):1891-2. doi: 10.1056/NEJMc1703369. No abstract available. PMID: 28492070 6:Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery. Jimenez-Rivera JJ, Iribarren-Sarrías JL, Martínez-Sanz R.N Engl J Med. 2017 May 11;376(19):1891. doi: 10.1056/NEJMc1703369. No abstract available. PMID: 28492069 7:Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery. Myles PS, Smith JA, Painter T.N Engl J Med. 2017 May 11;376(19):1893. doi: 10.1056/NEJMc1703369. No abstract available. PMID: 28489995 8:Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery. Milojevic M, Kappetein AP, Head SJ.N Engl J Med. 2017 May 11;376(19):1892. doi: 10.1056/NEJMc1703369. No abstract available. PMID: 28489994 9:Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery. Dawes TJ, Price S.N Engl J Med. 2017 May 11;376(19):1892-3. doi: 10.1056/NEJMc1703369. No abstract available. PMID: 28489993 Free Article10:Efficacy of functional microarray of microneedles combined with topical tranexamic acid for melasma: A randomized, self-controlled, split-face study. Xu Y, Ma R, Juliandri J, Wang X, Xu B, Wang D, Lu Y, Zhou B, Luo D.Medicine (Baltimore). 2017 May;96(19):e6897. doi: 10.1097/MD.0000000000006897. PMID: 28489798 Free PMC Article