Procaine HCl

• CAT Number: A000393
• CAS Number: 51-05-8
• Molecular Formula: C13H20N2O2 • HCl
• Molecular Weight: 272.80
• Purity: ≥95%
• Synonyms: Novocaine HCl
• Target: Cell Cycle/DNA Damage
• Solubility: Soluble in DMSO > 10 mM
• Storage: 3 years -20C powder
• IUPAC Name: 2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride
• InChI: InChI=1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H
• InChIKey: HCBIBCJNVBAKAB-UHFFFAOYSA-N
• SMILES: CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.Cl

Procaine hydrochloride（Cat No.:A000393）is an ester-type local anesthetic with the molecular formula C13H20N2O2·HCl, commonly used to induce temporary numbness during minor surgical or dental procedures. It works by blocking sodium ion influx in nerve cells, preventing nerve signal transmission and resulting in localized loss of sensation. Procaine HCl appears as a white crystalline powder, readily soluble in water, and is typically administered via injection. Though largely replaced by newer agents like lidocaine, it remains useful in specific applications. It has a rapid onset, short duration of action, and low systemic toxicity when properly dosed.

Reference

1.Epstein, Sidney, and Neal W. Chilton. "The clinical effectiveness of certain local anesthetics in dental procedures." Oral Surgery, Oral Medicine, Oral Pathology 12.1 (1959): 93-103.
2.Brau, Michael E., Werner Vogel, and Gunter Hempelmann. "Fundamental properties of local anesthetics: half-maximal blocking concentrations for tonic block of Na+ and K+ channels in peripheral nerve." Anesthesia & Analgesia 87.4 (1998): 885-889.
3.Hahnenkamp, K., et al. "Local anaesthetics inhibit signalling of human NMDA receptors recombinantly expressed in Xenopus laevis oocytes: role of protein kinase C." British journal of anaesthesia 96.1 (2006): 77-87.
4.Wang, Hong, Ying Zhang, and Shi-tong Li. "The effect of local anesthetics on the inhibition of adult muscle-type nicotinic acetylcholine receptors by nondepolarizing muscle relaxants." European journal of pharmacology 630.1-3 (2010): 29-33.
5.Fan, P., and F. F. Weight. "Procaine impairs the function of 5-HT3 receptor-ion channel complex in rat sensory ganglion neurons." Neuropharmacology 33.12 (1994): 1573-1579.