Procaine HCl

• CAT Number: A000393
• CAS Number: 51-05-8
• Molecular Formula: C13H20N2O2 • HCl
• Molecular Weight: 272.8
• Purity: ≥95%
• Synonyms: Novocaine HCl
• Target: Sodium Channel
• Solubility: Soluble in DMSO > 10 mM
• Storage: 3 years -20C powder
• IUPAC Name: 2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride
• InChI: InChI=1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H
• InChIKey: HCBIBCJNVBAKAB-UHFFFAOYSA-N
• SMILES: CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.Cl

Procaine Hydrochloride(CAS 51-05-8) is the hydrochloride salt form of Procaine, which is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.
Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel.
Procaine is an excitant of limbic system cells. 15 mg/kg Procaine increases cellular activity in amygdala ventral hippocampus, nucleus accumbens, temporal neocortex and ventromedial hypothalamus of awaken cat. Procaine facilitates transmission of evoked excitatory activity from the amygdala to the ventromedial hypothalamus.

Reference

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