Procaine HCl

  • CAT Number: A000393
  • CAS Number: 51-05-8
  • Molecular Formula: C13H20N2O2 • HCl
  • Molecular Weight: 272.8
  • Purity: ≥95%
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<span style="color:#000000;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">Procaine Hydrochloride(CAS&nbsp;51-05-8)&nbsp;is the hydrochloride salt form of&nbsp;Procaine, which&nbsp;is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 &mu;M, 0.296 mM and 45.5 &mu;M, which is also an inhibitor of 5-HT3 with K<sub>D</sub> of 1.7 &mu;M.<br />
Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel.<br />
Procaine is an excitant of limbic system cells. 15 mg/kg Procaine increases cellular activity in amygdala ventral hippocampus, nucleus accumbens, temporal neocortex and ventromedial hypothalamus of awaken cat. Procaine facilitates transmission of evoked excitatory activity from the amygdala to the ventromedial hypothalamus.</span></span></span>


Catalog Number A000393
CAS Number 51-05-8
Synonyms

Novocaine HCl

Molecular Formula C13H20N2O2 • HCl
Purity ≥95%
Target Sodium Channel
Solubility Soluble in DMSO > 10 mM
Storage 3 years -20C powder
IUPAC Name 2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride
InChI InChI=1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H
InChIKey HCBIBCJNVBAKAB-UHFFFAOYSA-N
SMILES CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.Cl
Reference

<span style="font-size:12px;">1.<span style="font-family: Arial, sans-serif;">Epstein, Sidney, and Neal W. Chilton. &quot;The clinical effectiveness of certain local anesthetics in dental procedures.&quot;&nbsp;</span><i style="font-family: Arial, sans-serif; font-size: 13px;">Oral Surgery, Oral Medicine, Oral Pathology</i><span style="font-family: Arial, sans-serif;">&nbsp;12.1 (1959): 93-103.<br />
2.</span><span style="font-family: Arial, sans-serif;">Brau, Michael E., Werner Vogel, and Gunter Hempelmann. &quot;Fundamental properties of local anesthetics: half-maximal blocking concentrations for tonic block of Na+ and K+ channels in peripheral nerve.&quot;&nbsp;</span><i style="font-family: Arial, sans-serif; font-size: 13px;">Anesthesia &amp; Analgesia</i><span style="font-family: Arial, sans-serif;">&nbsp;87.4 (1998): 885-889.<br />
3.</span><span style="font-family: Arial, sans-serif;">Hahnenkamp, K., et al. &quot;Local anaesthetics inhibit signalling of human NMDA receptors recombinantly expressed in Xenopus laevis oocytes: role of protein kinase C.&quot;&nbsp;</span><i style="font-family: Arial, sans-serif; font-size: 13px;">British journal of anaesthesia</i><span style="font-family: Arial, sans-serif;">&nbsp;96.1 (2006): 77-87.<br />
4.</span><span style="font-family: Arial, sans-serif;">Wang, Hong, Ying Zhang, and Shi-tong Li. &quot;The effect of local anesthetics on the inhibition of adult muscle-type nicotinic acetylcholine receptors by nondepolarizing muscle relaxants.&quot;&nbsp;</span><i style="font-family: Arial, sans-serif; font-size: 13px;">European journal of pharmacology</i><span style="font-family: Arial, sans-serif;">&nbsp;630.1-3 (2010): 29-33.<br />
5.</span><span style="font-family: Arial, sans-serif;">Fan, P., and F. F. Weight. &quot;Procaine impairs the function of 5-HT3 receptor-ion channel complex in rat sensory ganglion neurons.&quot;&nbsp;</span><i style="font-family: Arial, sans-serif; font-size: 13px;">Neuropharmacology</i><span style="font-family: Arial, sans-serif;">&nbsp;33.12 (1994): 1573-1579.</span></span>

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