For research use only. Not for therapeutic Use.
DAPT (CAT: A000703) is a potent and selective γ-secretase inhibitor widely employed in neurological and immunological research. As a non-transition-state analogue, it is one of the most extensively studied GSIs in experimental models. DAPT effectively reduces amyloid-β (Aβ) production in human primary neuronal cultures with reported IC₅₀ values of 115–200 nM, making it a key tool in Alzheimer’s disease research. Additionally, DAPT blocks Notch signaling with an IC₅₀ of ~500 nM, enabling studies on cell differentiation, autoimmune disorders, and lymphoproliferative diseases. Its dual relevance to neurodegeneration and immunology establishes DAPT as a versatile reference compound in biomedical investigations.
| CAS Number | 208255-80-5 |
| Synonyms | LY-374973 |
| Molecular Formula | C₂₃H₂₆F₂N₂O₄ |
| Purity | ≥95% |
| Target | Stem Cell/Wnt |
| Solubility | >21.6mg/mL in DMSO |
| Storage | 3 years -20C powder |
| IUPAC Name | tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate |
| InChI | InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1 |
| InChIKey | DWJXYEABWRJFSP-XOBRGWDASA-N |
| SMILES | CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
