Roxatidine Acetate Hydrochloride

  • CAT Number: A000643
  • CAS Number: 93793-83-0
  • Molecular Formula: C19H29ClN2O4
  • Molecular Weight: 384.9
  • Purity: ≥95%
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Roxatidine Acetate Hydrochloride is a histamine H2-receptor antagonist used in ulcer treatment. This compound has been found to inhibit platelet function.

Catalog Number A000643
CAS Number 93793-83-0
Molecular Formula

C19H29ClN2O4

Purity 95%
Target Histamine Receptor
Solubility Soluble in DMSO > 10 mM
Storage -20°C
InChI 1S/C19H28N2O4.ClH/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21;/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23);1H
InChIKey FEWCTJHCXOHWNL-UHFFFAOYSA-N
SMILES CC(=O)OCC(=O)NCCCOC1=CC=CC(=C1)CN2CCCCC2.Cl
Reference

1: Nakamura H, Kawashima H, Azuma R, Sato I, Nagao K, Miyazawa K.
Pharmacokinetics of the H(2) blocker roxatidine acetate hydrochloride in
pediatric patients, in comparison with healthy adult volunteers. Drug Metab
Pharmacokinet. 2012;27(4):422-9. Epub 2012 Jan 31. PubMed PMID: 22293541.
<br>

2: Maheshwari A, Sharma M, Sharma D. Investigation of the binding of roxatidine
acetate hydrochloride with cyclomaltoheptaose (β-cyclodextrin) using IR and NMR
spectroscopy. Carbohydr Res. 2011 Sep 27;346(13):1809-13. doi:
10.1016/j.carres.2011.07.003. Epub 2011 Jul 18. PubMed PMID: 21816394.
<br>

3: Igawa K, Matsunaga T, Yokozeki H, Nishioka K. Erythrodermic drug eruption due
to roxatidine acetate hydrochloride. Clin Exp Dermatol. 2005 May;30(3):304-5.
PubMed PMID: 15807703.
<br>

4: Ali SM, Maheshwari A, Asmat F. Complexation of roxatidine acetate
hydrochloride with beta-cyclodextrin: NMR spectroscopic study. Pharmazie. 2004
Aug;59(8):653-5. PubMed PMID: 15378861.
<br>

5: Yasutake K, Amano M, Mizokami Y, Kubota S, Fukumoto H, Imamura Y, Yokoya H,
Irie K. Effects of changing the type of H2-blocker in the treatment of
H2-blocker-resistant ulcers: comparison of roxatidine acetate hydrochloride and
other H2-blockers. J Int Med Res. 1998 Jan-Feb;26(1):25-36. PubMed PMID: 9513074.

<br>
6: Nagai N, Furuhata M, Ogata H. Drug interactions between theophylline and
H2-antagonists, roxatidine acetate hydrochloride and cimetidine: pharmacokinetic
analysis in rats in vivo. Biol Pharm Bull. 1995 Nov;18(11):1610-3. PubMed PMID:
8593491.
<br>

7: Kawanishi M, Enomoto A, Shimada Y, Kurokawa Y. [Clinical evaluation of
roxatidine acetate hydrochloride injection as preanesthetic medication]. Masui.
1991 Sep;40(9):1364-70. Japanese. PubMed PMID: 1682516.
<br>

8: Kojima A, Andoh K, Shima T, Koga Y, Hashimoto Y. [The effect of oral
administration of roxatidine acetate hydrochloride 3 hours prior to the operation
on pH and volume of gastric juice]. Masui. 1991 Mar;40(3):451-3. Japanese. PubMed
PMID: 1677048.
<br>

9: Tanioka H, Terahara A, Sasaki Y. Radiographic assessment of nocturnal gastric
juice secretion after administration of roxatidine acetate hydrochloride. Clin
Ther. 1991 Jan-Feb;13(1):22-4. PubMed PMID: 1674230.
<br>

10: Yoshimura N, Takeuchi H, Ogata H, Ishioka T, Aoi R. Effects of roxatidine
acetate hydrochloride and cimetidine on the pharmacokinetics of theophylline in
healthy subjects. Int J Clin Pharmacol Ther Toxicol. 1989 Jun;27(6):308-12.
PubMed PMID: 2737801.

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