ZM 306416

• CAT Number: I004594
• CAS Number: 690206-97-4
• Molecular Formula: C16H13ClFN3O2
• Molecular Weight: 333.747
• Purity: ≥95%
• Target: Src
• Solubility: DMSO: 67 mg/mL, H2O: ＜ 1 mg/mL
• Storage: 3 years -20C powder
• IC50: 0.67uM(VEGFR); 0.33±0.08uM(Src); 1.3±0.2 μM(Abl)
• IUPAC Name: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine
• InChI: InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(17)5-11(12)18/h3-8H,1-2H3,(H,19,20,21)
• InChIKey: YHUIUSRCUKUUQA-UHFFFAOYSA-N
• SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Cl)F)OC

ZM-306416 (CAT: I004594) is a potent vascular endothelial growth factor receptor (VEGFR) inhibitor with specific activity against Flk-1 (KDR) and Flt receptors. It displays an inhibitory effect on Flk-1 (KDR) with an IC50 value of 100 nM and on Flt with an IC50 value of 2 μM. By targeting VEGFRs, ZM-306416 interferes with the signaling pathways involved in angiogenesis and vascular permeability, which are critical processes in tumor growth and metastasis.

Reference

[1]. Han SY, Park SS, Lee WG, Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases. Bioorg Med Chem Lett. 2006 Jan 1;16(1):129-33.
[2]. Antczak C, Mahida JP, Bhinder B, A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery. J Biomol Screen. 2012 Aug;17(7):885-99.