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Zidebactam

Zidebactam

  • CAT Number: I010149
  • CAS Number: 1436861-97-0
  • Molecular Formula: C13H21N5O7S
  • Molecular Weight: 391.399
  • Purity: ≥95%
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Zidebactam (Cat.No:I010149) is a promising antimicrobial agent that has captured the interest of the scientific community. This novel compound shows potent activity against multi-drug-resistant bacteria, making it a potential solution to combat antibiotic resistance. Research on Zidebactam is ongoing, with hopes of developing effective therapies to address the pressing global health challenge of resistant infections.

Catalog Number I010149
CAS Number 1436861-97-0
Molecular Formula

C13H21N5O7S

Purity 95%
Solubility Soluble in DMSO, not in water
Storage 0 - 4 °C for short term, or -20 °C for long term
IUPAC Name [(2S,5R)-7-oxo-2-[[[(3R)-piperidine-3-carbonyl]amino]carbamoyl]-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate
InChI InChI=1S/C13H21N5O7S/c19-11(8-2-1-5-14-6-8)15-16-12(20)10-4-3-9-7-17(10)13(21)18(9)25-26(22,23)24/h8-10,14H,1-7H2,(H,15,19)(H,16,20)(H,22,23,24)/t8-,9-,10+/m1/s1
InChIKey YCZPXRQPDCXTIO-BBBLOLIVSA-N
SMILES C1CC(CNC1)C(=O)NNC(=O)C2CCC3CN2C(=O)N3OS(=O)(=O)O
Reference

</br>1:WCK 5222 (cefepime/zidebactam) antimicrobial activity tested against Gram-negative organisms producing clinically relevant β-lactamases. Sader HS, Rhomberg PR, Flamm RK, Jones RN, Castanheira M.J Antimicrob Chemother. 2017 Jun 1;72(6):1696-1703. doi: 10.1093/jac/dkx050. PMID: 28333332 </br>2:WCK 5107 (Zidebactam) &amp; WCK 5153: Novel inhibitors of PBP2 showing potent /β-lactam enhancer/ activity against <i>Pseudomonas aeruginosa</i>, including multidrug-resistant metallo-β-lactamase-producing high-risk clones. Moya B, Barcelo IM, Bhagwat S, Patel M, Bou G, Papp-Wallace KM, Bonomo RA, Oliver A.Antimicrob Agents Chemother. 2017 Mar 13. pii: AAC.02529-16. doi: 10.1128/AAC.02529-16. [Epub ahead of print] PMID: 28289035 </br>3:WCK 5222 (Cefepime-Zidebactam) Antimicrobial Activity against Clinical Isolates of Gram-Negative Bacteria Collected Worldwide in 2015. Sader HS, Castanheira M, Huband M, Jones RN, Flamm RK.Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e00072-17. doi: 10.1128/AAC.00072-17. Print 2017 May. PMID: 28242660 </br>4:In vitro activity of cefepime/zidebactam (WCK 5222) against Gram-negative bacteria. Livermore DM, Mushtaq S, Warner M, Vickers A, Woodford N.J Antimicrob Chemother. 2017 Feb 3. doi: 10.1093/jac/dkw593. [Epub ahead of print] No abstract available. PMID: 28158732

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