Vatalanib Dihydrochloride

• CAT Number: I002633
• CAS Number: 212141-51-0
• Molecular Formula: C₂₀H₁₅ClN₄•2HCl
• Molecular Weight: 419.73
• Purity: ≥95%
• Synonyms: N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine;dihydrochloride
• Target: VEGFR
• Solubility: DMSO:32mg/mL
• Storage: 3 years -20℃ powder
• IC50: 37 nM (VEGFR2/KDR) [1]
• InChI: InChI=1S/C20H15ClN4.2ClH/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14;;/h1-12H,13H2,(H,23,25);2*1H
• InChIKey: AZUQEHCMDUSRLH-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl

Vatalanib Dihydrochloride (Cat.No:I002633) is a potent and selective inhibitor of vascular endothelial growth factor receptor (VEGFR). It has shown promising potential in inhibiting tumor angiogenesis and is being studied for its therapeutic role in cancer treatment. Its targeted mechanism makes it an intriguing candidate for anti-cancer therapies.

Reference

[1]. Wood JM, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000, 60(8), 2178-2189.
[2]. Murakami M, et al. Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-α/5-fluorouracil therapy for hepatocellular carcinoma cells. Ann Surg Oncol. 2011, 18(2), 589-596.