Vancomycin HCl

• CAT Number: A000291
• CAS Number: 1404-93-9
• Molecular Formula: C66H75Cl2N9O24 • XHCl
• Molecular Weight: 1485.7
• Purity: ≥95%
• Target: Antibiotic
• Solubility: Limited solubility
• Storage: 3 years -20C powder
• InChIKey: LCTORFDMHNKUSG-XTTLPDOESA-N

Vancomycin HCl is a bactericidal glycopeptide antibiotic and has been used to treat infections caused by multi drug resistant bacteria including methicillin resistant Staphylococcus aureus (MRSA).Vancomycin prevents peptidoglycan synthesis by two separate mechanisms. One mechanism prevents N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) from linking together forming the peptidoglycan backbone. The second mechanism prevents crosslinking between amino acid residues in the peptidoglycan chain.

Reference

Courvalin, Patrice. /Vancomycin Resistance in Gram-Positive Cocci./ Oxford Journals(2006): 25-34. Clinical Infectious Diseaes. Web. 21 Aug. 2012.Pollock, H.M., Holt J., and Murray C., Comparison of susceptibilities of anaerobic bacteria to cefemenoxime, ceftriaxone and other antimicrobial compounds, Antimicrob. Agents Chemother., Vol. 23, pp.780-783, 1983Silva J.A. and Fukai S., The impact of carbenicillin, cefotaxime and vancomycin on chrysanthemum and tobacco TCL morphogenesis and Agrobacterium growth, J. Appl. Hort., Vol. 3(1), pp. 3-12, 2001.Joshi, S., Ray, P., Manchanda, V., Bajaj, J., Chitnis, D. S., Gautam, V., &…Balaji, V. (2013). Methicillin resistant Staphylococcus aureus (MRSA) in India: Prevalence & susceptibility pattern. Indian Journal Of Medical Research, 137(2), 363-369