For research use only. Not for therapeutic Use.
UNC2399（Cat No.:I044502）is a selective, cell-permeable small-molecule inhibitor targeting the histone methyltransferase G9a (EHMT2), which catalyzes the dimethylation of histone H3 at lysine 9 (H3K9me2), a key epigenetic mark associated with gene silencing. By inhibiting G9a activity, UNC2399 reduces H3K9me2 levels, reactivating silenced genes involved in differentiation and tumor suppression. It has been utilized in studies on cancer, neurodevelopment, and epigenetic regulation. UNC2399 offers improved selectivity and potency compared to earlier G9a inhibitors, making it a valuable chemical probe for dissecting G9a’s role in chromatin biology and transcriptional control.
| CAS Number | 2412791-72-9 |
| Molecular Formula | C67H104N10O17S |
| Purity | ≥95% |
| IUPAC Name | 6-[6-[4-[3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoyl]piperazin-1-yl]pyridin-3-yl]-N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-1-propan-2-ylindazole-4-carboxamide |
| InChI | InChI=1S/C67H104N10O17S/c1-5-8-52-43-51(4)72-66(81)56(52)47-70-65(80)55-44-54(45-59-57(55)48-71-77(59)50(2)3)53-11-12-61(69-46-53)75-15-17-76(18-16-75)63(79)13-19-83-21-23-85-25-27-87-29-31-89-33-35-91-37-39-93-41-42-94-40-38-92-36-34-90-32-30-88-28-26-86-24-22-84-20-14-68-62(78)10-7-6-9-60-64-58(49-95-60)73-67(82)74-64/h11-12,43-46,48,50,58,60,64H,5-10,13-42,47,49H2,1-4H3,(H,68,78)(H,70,80)(H,72,81)(H2,73,74,82)/t58-,60-,64-/m0/s1 |
| InChIKey | PSDIDGKZEPMSHC-FRQYIUQJSA-N |
| SMILES | CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@H]6[C@@H]7[C@H](CS6)NC(=O)N7)C(C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
