Bay 65-1942 hydrochloride

• CAT Number: I004255
• CAS Number: 600734-06-3
• Molecular Formula: C22H26ClN3O4
• Molecular Weight: 431.91
• Purity: ≥95%
• Target: IκB/IKK
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: (7E)-7-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-5-[(3S)-piperidin-3-yl]-4,8-dihydro-1H-pyrido[2,3-d][1,3]oxazin-2-one;hydrochloride
• InChI: InChI=1S/C22H25N3O4.ClH/c26-18-4-1-5-19(28-11-13-6-7-13)20(18)17-9-15(14-3-2-8-23-10-14)16-12-29-22(27)25-21(16)24-17;/h1,4-5,9,13-14,23-24H,2-3,6-8,10-12H2,(H,25,27);1H/b20-17-;/t14-;/m1./s1
• InChIKey: KSTOJOVDFHFWCE-VHNKIRJFSA-N
• SMILES: C1CC(CNC1)C2=CC(=C3C(=O)C=CC=C3OCC4CC4)NC5=C2COC(=O)N5.Cl

Bay 65-1942 hydrochloride (Cat.No:I004255) is a selective inhibitor of the TRPV4 ion channel, which is involved in various physiological and pathological processes such as osmoregulation, inflammation, and pain perception. It has potential applications in the treatment of diseases such as osteoarthritis, neuropathic pain, and respiratory disorders.

Reference

[1]. Inhibition of IκB kinase-β protects dopamine neurons against lipopolysaccharide-induced neurotoxicity By Zhang, Feng; Qian, Li; Flood, Patrick M.; Shi, Jing-Shan; Hong, Jau-Shyong; Gao, Hui-Ming J Pharmacol Exp Ther. 2010 June; 333(3): 822-833.
[2]. Moss NC, et al. IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2248-53.