UBCS039

• CAT Number: I019198
• CAS Number: 358721-70-7
• Molecular Formula: C₁₆H₁₃N₃
• Molecular Weight: 247.29
• Purity: ≥95%
• Storage: 2-8°C
• IUPAC Name: 4-pyridin-3-yl-4,5-dihydropyrrolo[1,2-a]quinoxaline
• InChI: InChI=1S/C16H13N3/c1-2-7-14-13(6-1)18-16(12-5-3-9-17-11-12)15-8-4-10-19(14)15/h1-11,16,18H
• InChIKey: BSOBGTYXYGHUTD-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)NC(C3=CC=CN32)C4=CN=CC=C4

UBCS039 (Cat No.: I019198) is a synthetic compound and the first known SIRT6 activator, characterized by an EC50 of 38 μM. This compound has demonstrated the ability to induce time-dependent activation of autophagy in various human tumor cell lines. The activation of SIRT6 and autophagy is of interest in cancer research and the development of potential therapeutic strategies. If you need to, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

[1]. Weijie You, et al. Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules. Angew. Chem. Int. Ed. 2017, 56, 1007-1011.[2]. Sara Iachettini, et al. Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells. Cell Death and Disease (2018) 9:996.