Tyrphostin A9

• CAT Number: I000285
• CAS Number: 10537-47-0
• Molecular Formula: C18H22N2O
• Molecular Weight: 282.4
• Purity: ≥95%
• Target: VEGFR
• Solubility: 10 mM in DMSO
• Storage: 3 years -20C powder
• InChI: InChI=1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3
• InChIKey: MZOPWQKISXCCTP-UHFFFAOYSA-N
• SMILES: CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(/C=C(C#N)C#N)=C1

Tyrphostin A9 (Cat.No:I000285) is a synthetic compound known as a tyrosine kinase inhibitor. It selectively inhibits the activity of various tyrosine kinases, interfering with cell signaling pathways involved in cell growth and proliferation. Tyrphostin A9 has been studied for its potential therapeutic applications in cancer and other diseases related to dysregulated tyrosine kinase activity.

Reference

1:A receptor tyrosine kinase inhibitor, Tyrphostin A9 induces cancer cell death through Drp1 dependent mitochondria fragmentation. Park SJ, Park YJ, Shin JH, Kim ES, Hwang JJ, Jin DH, Kim JC, Cho DH.Biochem Biophys Res Commun. 2011 May 13;408(3):465-70. doi: 10.1016/j.bbrc.2011.04.053. Epub 2011 Apr 19. PMID: 21527248 2:Abnormal localisation and hyperclustering of (alpha)(V)(beta)(3) integrins and associated proteins in Src-deficient or tyrphostin A9-treated osteoclasts. Lakkakorpi PT, Nakamura I, Young M, Lipfert L, Rodan GA, Duong LT.J Cell Sci. 2001 Jan;114(Pt 1):149-160. PMID: 11112699 Free Article3:Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells. Thyberg J.Eur J Cell Biol. 1998 May;76(1):33-42. PMID: 9650781 4:Tyrphostin A9 inhibits calcium release-dependent phosphorylations and calcium entry via calcium release-activated channel in Jurkat T cells. Marhaba R, Mary F, Pelassy C, Stanescu AT, Aussel C, Breittmayer JP.J Immunol. 1996 Aug 15;157(4):1468-73. PMID: 8759727