Tylvalosin tartrate

• CAT Number: I037658
• CAS Number: 63428-13-7
• Molecular Formula: C57H93NO25
• Molecular Weight: 1192.35
• Purity: 80%
• Solubility: To be determined
• Storage: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
• IUPAC Name: (2S,3S,4R,6S)-6-(((2R,3S,4R,5R,6R)-6-(((4R,5S,6S,7R,9R,11E,13E,15R,16R)-4-acetoxy-16-ethyl-15-((((2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)-5,9,13-trimethyl-2,10-dioxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl)oxy)-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate (2R,3R)-2,3-dihydroxysuccinate
• InChI: InChI=1S/C53H87NO19.C4H6O6/c1-16-38-36(26-65-52-49(64-15)48(63-14)44(60)31(7)67-52)22-28(4)17-18-37(57)29(5)23-35(19-20-55)46(30(6)39(69-34(10)56)24-41(59)70-38)73-51-45(61)43(54(12)13)47(32(8)68-51)72-42-25-53(11,62)50(33(9)66-42)71-40(58)21-27(2)3;5-1(3(7)8)2(6)4(9)10/h17-18,20,22,27,29-33,35-36,38-39,42-52,60-62H,16,19,21,23-26H2,1-15H3;1-2,5-6H,(H,7,8)(H,9,10)/b18-17+,28-22+;/t29-,30+,31-,32-,33+,35+,36-,38-,39-,42+,43-,44-,45-,46-,47-,48-,49-,50+,51+,52-,53-;1-,2-/m11/s1
• InChIKey: OLLSDNUHBJHKJS-XKORHJEPSA-N
• SMILES: OC([C@@H]([C@H](C(O)=O)O)O)=O.CN([C@@H]([C@@H]1O[C@H]2C[C@@]([C@@H](OC(CC(C)C)=O)[C@H](C)O2)(C)O)[C@@H](O)[C@H](O[C@H]3[C@@H](CC=O)C[C@@H](C)C(/C=C/C(C)=C/[C@H](CO[C@H]4[C@H](OC)[C@H](OC)[C@H](O)[C@@H](C)O4)[C@@H](CC)OC(C[C@@H](OC(C)=O)[C@@H]3C)=O)=O)O[C@@H]1C)C

Tylvalosin (Cat.No:I037658) is a macrolide antibiotic. It is active against S. aureus, E. coli, and P. multocida (MICs = 2, 128, and 128 µg/ml, respectively). Tylvalosin (5 and 10 µg/ml) reduces LPS-induced production of pro-inflammatory cytokines, prostaglandin E2 (PGE2), and nitric oxide in RAW 264.7 cells. It reduces the severity of lung lesions in pigs infected with M. hyopneumoniae and P. multocida when administered at a dose of 10 mg/kg per day in the drinking water. Formulations containing tylvalosin have been used in the treatment and metaphylaxis of enzootic pneumonia caused by M. hyopneumoniae in pigs.

Reference

1: Guedes RM, França SA, Machado GS, Blumer MA, da Costa Cruz EC Jr. Use of tylvalosin-medicated feed to control porcine proliferative enteropathy. Vet Rec. 2009 Sep 19;165(12):342-5. doi: 10.1136/vr.165.12.342. PMID: 19767637.