Tubastatin TFA salt

• CAT Number: I037589
• CAS Number: 1239034-70-8
• Molecular Formula: C22H22F3N3O4
• Molecular Weight: 449.4302
• Purity: 98%
• Solubility: Soluble in DMSO
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-Hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide TFA salt
• InChI: InChI=1S/C20H21N3O2.C2HF3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25;3-2(4,5)1(6)7/h2-9,25H,10-13H2,1H3,(H,21,24);(H,6,7)
• InChIKey: AVAOVICSJJIYRZ-UHFFFAOYSA-N
• SMILES: ONC(C1=CC=C(CN2C(CCN(C)C3)=C3C4=C2C=CC=C4)C=C1)=O.FC(F)(F)C(O)=O

Tubastatin TFA salt (CAT: I037589) is a highly potent inhibitor of histone deacetylase 6 (HDAC6). It exhibits strong selectivity for HDAC6 over other HDAC isoforms. HDAC6 is primarily responsible for the deacetylation of non-histone proteins, including α-tubulin. By inhibiting HDAC6, Tubastatin TFA salt promotes tubulin acetylation, which can affect cellular processes such as microtubule dynamics, cell migration, and protein degradation. Tubastatin TFA salt has been widely used as a tool compound in research studies to investigate the role of HDAC6 and its potential therapeutic applications in various diseases.