Tiadinil

• CAT Number: I002717
• CAS Number: 223580-51-6
• Molecular Formula: C11H10ClN3OS
• Molecular Weight: 267.73
• Purity: 95%
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: N-(3-chloro-4-methylphenyl)-4-methylthiadiazole-5-carboxamide
• InChI: InChI=1S/C11H10ClN3OS/c1-6-3-4-8(5-9(6)12)13-11(16)10-7(2)14-15-17-10/h3-5H,1-2H3,(H,13,16)
• InChIKey: VJQYLJSMBWXGDV-UHFFFAOYSA-N
• SMILES: CC1=C(SN=N1)C(=O)NC1=CC=C(C)C(Cl)=C1

Tiadinil (CAT: I002717) is a synthetic fungicide that belongs to the class of benzamide compounds. It is primarily used for the control of various fungal diseases in crops. Tiadinil acts by inhibiting the enzyme isoprenylcysteine carboxyl methyltransferase (ICMT), which is involved in the prenylation process of proteins. By inhibiting ICMT, tiadinil disrupts the proper function of prenylated proteins in fungal cells, leading to the inhibition of fungal growth and the prevention of disease development. It has shown effectiveness against a range of plant pathogenic fungi, making it valuable for crop protection. Tiadinil is typically applied as a foliar spray or seed treatment in agricultural practices.

Reference

[1]. Maeda T, et al. Tiadinil, a plant activator of systemic acquired resistance, boosts the production of herbivore-induced plant volatiles that attract the predatory mite Neoseiulus womersleyi in the tea plant Camellia sinensis. Exp Appl Acarol. 2012 Nov;58(3):247-58.
[2]. Chen X, et al. Determination of tiadinil and its metabolite in flue-cured tobacco. J Chromatogr Sci. 2014 Aug;52(7):624-8.