Thienopyridone

• CAT Number: I015530
• CAS Number: 1018454-97-1
• Molecular Formula: C₁₃H₁₀N₂OS
• Molecular Weight: 242.3
• Purity: ≥95%

Thienopyridone (CAT: I015530) is a potent and selective inhibitor of phosphatase of regenerating liver (PRL) phosphatases, specifically targeting PRL-1, PRL-2, and PRL-3 with IC50 values of 173 nM, 277 nM, and 128 nM, respectively. It exhibits minimal effects on other phosphatases. Thienopyridone demonstrates anticancer effects by inducing p130Cas cleavage, apoptosis, and inhibiting tumor cell anchorage-independent growth in soft agar. It down-regulates total p130Cas in HeLa cells, leading to caspase-mediated cell apoptosis. Thienopyridone also suppresses HUVEC migration without affecting proliferation. These findings highlight the potential of Thienopyridone as an anticancer agent and its ability to modulate cellular processes involved in tumor progression and angiogenesis.

Reference

[1]. Daouti S, et al. A selective phosphatase of regenerating liver phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavage. Cancer Res. 2008 Feb 15;68(4):1162-9.