Terizidone

• CAT Number: R047000
• CAS Number: 25683-71-0
• Molecular Formula: C14H14N4O4
• Molecular Weight: 302.29
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: 4-[[4-[(3-oxo-1,2-oxazolidin-4-yl)iminomethyl]phenyl]methylideneamino]-1,2-oxazolidin-3-one
• InChI: InChI=1S/C14H14N4O4/c19-13-11(7-21-17-13)15-5-9-1-2-10(4-3-9)6-16-12-8-22-18-14(12)20/h1-6,11-12H,7-8H2,(H,17,19)(H,18,20)
• InChIKey: ODKYYBOHSVLGNU-UHFFFAOYSA-N
• SMILES: C1C(C(=O)NO1)N=CC2=CC=C(C=C2)C=NC3CONC3=O

Terizidone is a drug used in the treatment of tuberculosis. Terizidone is used mainly used in multi-drug-resistant tuberculosis (MDR-TB) in conjunction with other second-line drugs. It is a derivate of cycloserine and it is bacteriostatic.

Reference

1:Safety of cycloserine and terizidone for the treatment of drug-resistant tuberculosis: a meta-analysis. Hwang TJ, Wares DF, Jafarov A, Jakubowiak W, Nunn P, Keshavjee S.Int J Tuberc Lung Dis. 2013 Oct;17(10):1257-66. doi: 10.5588/ijtld.12.0863. Epub 2013 Jun 3. Review. PMID: 23735593 2:Terizidone. Vora A.J Assoc Physicians India. 2010 Apr;58:267-8. No abstract available. PMID: 21046890 3:[Tolerability to terizidone (TZ) in the treatment of pulmonary tuberculosis in dialyzed patients]. Galietti F, Giorgis GE, Oliaro A, Boaro D, Ardizzi A, Barberis S, Massaglia GM.Minerva Med. 1991 Jul-Aug;82(7-8):477-81. Italian. PMID: 1922892 4:[Contribution to the therapeutic use of terizidone]. Semenitz E, Madersbacher H, Spanudakis S.Wien Med Wochenschr. 1976 Nov 5;126(45):640-2. German. No abstract available. PMID: 1007295 5:[Antibacterial activity of urea combined with terizidone on pathogenic strains isolated from urine cultures]. Costa AL.Minerva Urol. 1976 May-Jun;28(3):109-11. Italian. No abstract available. PMID: 1018703 6:Pharmacokinetics of cycloserine and terizidone. A comparative study. Zítková L, Tousek J.Chemotherapy. 1974;20(1):18-28. No abstract available. PMID: 4845674 7:[Terizidone and phenazopyridine–an effective preparation for treatment of infections of the urinary tract during pregnancy (author/’s transl)]. Pavlík V, Hradecký L.Cesk Gynekol. 1973 Nov;38(9):660-1. Czech. No abstract available. PMID: 4765157 8:[Triple placebo test for comparison of side effects of terizidone (terivalidin) and cycloserine]. Böszörményi M.Int J Clin Pharmacol. 1973 Aug;8(1):37-41. German. No abstract available. PMID: 4580381 9:[Results of clinical trials of a new antitubercular agent, terizidone (Terivalidine)]. Zrilić V, Mijatović M, Mirković S, Muzikravić T.Plucne Bolesti Tuberk. 1972 Apr-Jun;24(2):89-98. Croatian. No abstract available. PMID: 4565191 10:[Preliminary note on Terizidone]. Dumon JF, Aimone J, Dumon G.Mars Med. 1972;109(11):730-2. French. No abstract available. PMID: 4662237