Teicoplanin

  • CAT Number: A000660
  • CAS Number: 61036-62-2
  • Molecular Formula: C88H97Cl2N9O33
  • Molecular Weight: 1879.674
  • Purity: ≥95%
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Teicoplanin is an antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and Enterococcus faecalis. It is a glycopeptide antiobiotic extracted from Actinoplanes teichomyceticus, with a similar spectrum of activity to vancomycin. Its mechanism of action is to inhibit bacterial cell wall synthesis. Teicoplanin is marketed by Sanofi-Aventis under the trade name Targocid. Oral teicoplanin has been demonstrated to be effective in the treatment of pseudomembranous colitis and Clostridium difficile-associated diarrhoea, with comparable efficacy with vancomycin.

Catalog Number A000660
CAS Number 61036-62-2
Molecular Formula

C88H97Cl2N9O33

Purity 95%
Storage -20°C
InChIKey YMWQIYMUNZBOOV-JCNLWGGRSA-N
Reference

1: Cazaubon Y, Venisse N, Mimoz O, Maire P, Ducher M, Bourguignon L, Goutelle S.
Population pharmacokinetics of teicoplanin administered by subcutaneous or
intravenous route and simulation of optimal loading dose regimen. J Antimicrob
Chemother. 2017 Oct 1;72(10):2804-2812. doi: 10.1093/jac/dkx242. PubMed PMID:
29091222.
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2: Boast A, Gwee A, Gwee A. Teicoplanin-Should We Be Doing Routine Therapeutic
Drug Monitoring in Children? Pediatr Infect Dis J. 2017 Nov;36(11):1110. doi:
10.1097/INF.0000000000001642. PubMed PMID: 29023347.

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3: Ramos-Martín V, Johnson A, McEntee L, Farrington N, Padmore K, Cojutti P, Pea
F, Neely MN, Hope WW. Pharmacodynamics of teicoplanin against MRSA. J Antimicrob
Chemother. 2017 Sep 11. doi: 10.1093/jac/dkx289. [Epub ahead of print] PubMed
PMID: 28962026.
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4: Ismail OH, Antonelli M, Ciogli A, Villani C, Cavazzini A, Catani M, Felletti
S, Bell DS, Gasparrini F. Future perspectives in high efficient and ultrafast
chiral liquid chromatography through zwitterionic teicoplanin-based 2-μm
superficially porous particles. J Chromatogr A. 2017 Oct 20;1520:91-102. doi:
10.1016/j.chroma.2017.09.008. Epub 2017 Sep 6. PubMed PMID: 28911942.
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5: Ramos-Martín V, Neely MN, Padmore K, Peak M, Beresford MW, Turner MA, Paulus
S, López-Herce J, Hope WW. Tools for the Individualized Therapy of Teicoplanin
for Neonates and Children. Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii:
e00707-17. doi: 10.1128/AAC.00707-17. Print 2017 Oct. PubMed PMID: 28760897;
PubMed Central PMCID: PMC5610524.
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6: Knafl D, Thalhammer F, Vossen MG. In-vitro release pharmacokinetics of
amikacin, teicoplanin and polyhexanide in a platelet rich fibrin-layer (PRF)-a
laboratory evaluation of a modern, autologous wound treatment. PLoS One. 2017 Jul
7;12(7):e0181090. doi: 10.1371/journal.pone.0181090. eCollection 2017. PubMed
PMID: 28686663; PubMed Central PMCID: PMC5501641.
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7: Erratum: Intrathecal baclofen pump infection treated by adjunct intrareservoir
teicoplanin instillation. Surg Neurol Int. 2017 Jun 13;8:119. doi:
10.4103/2152-7806.207945. eCollection 2017. PubMed PMID: 28680738; PubMed Central
PMCID: PMC5482158.
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8: Nakano T, Nakamura T, Nakamura Y, Irie K, Sato K, Matsuo K, Imakyure O, Ogata
K, Mishima K, Kamimura H. Effects of Teicoplanin on the PT-INR Controlled by
Warfarin in Infection Patients. Yakugaku Zasshi. 2017;137(7):909-916. doi:
10.1248/yakushi.17-00023. Japanese. PubMed PMID: 28674307.

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9: Wi J, Noh H, Min KL, Yang S, Jin BH, Hahn J, Bae SK, Kim J, Park MS, Choi D,
Chang MJ. Population Pharmacokinetics and Dose Optimization of Teicoplanin during
Venoarterial Extracorporeal Membrane Oxygenation. Antimicrob Agents Chemother.
2017 Aug 24;61(9). pii: e01015-17. doi: 10.1128/AAC.01015-17. Print 2017 Sep.
PubMed PMID: 28674057; PubMed Central PMCID: PMC5571348.

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10: Takechi K, Yanagawa H, Zamami Y, Ishizawa K, Tanaka A, Araki H. Evaluation of
factors associated with the achievement of an optimal teicoplanin trough
concentration&#8233;. Int J Clin Pharmacol Ther. 2017 Aug;55(8):672-677. doi:
10.5414/CP203009. PubMed PMID: 28655381.

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