Suramin

• CAT Number: I001761
• CAS Number: 145-63-1
• Molecular Formula: C51H40N6O23S6
• Molecular Weight: 1297.28
• Purity: ≥95%
• Target: P2Y Receptor antagonist
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: 8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonic acid
• InChI: InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)
• InChIKey: FIAFUQMPZJWCLV-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)C

Suramin（Cat No.:I001761） is a versatile compound with various pharmacological activities. It acts as a reversible, competitive inhibitor of protein tyrosine phosphatases (PTPases). It also exhibits potent inhibitory effects on sirtuins, including SirT1, SirT2, and SirT5. Suramin competes with reverse transcriptase and inhibits DNAtopoisomeraseII. It shows potent inhibition of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp). Additionally, it inhibits IP5K and possesses antiparasitic, antitumor, and antiangiogenic properties. With its broad range of activities, suramin holds promise for various therapeutic applications in the treatment of diseases including cancer, parasitic infections, and viral infections.

Reference

[1]. Darsaud A, et al. Megazol combined with suramin improves a new diagnosis index of the early meningo-encephalitic phase of experimental African trypanosomiasis. Trop Med Int Health. 2004 Jan;9(1):83-91.
[2]. Anderson J, et al. Further studies on the treatment of ocular onchocerciasis with diethylcarbamazine and suramin. Br J Ophthalmol. 1978 Jul;62(7):450-7.