Sulphadimethoxine

• CAT Number: A001171
• CAS Number: 122-11-2
• Molecular Formula: C12H14N4O4S
• Molecular Weight: 310.328
• Purity: ≥95%
• Storage: 3 years -20C powder
• IUPAC Name: 4-amino-N-(2,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
• InChI: InChI=1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)
• InChIKey: ZZORFUFYDOWNEF-UHFFFAOYSA-N
• SMILES: COC1=NC(=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N)OC

Sulfadimethoxine is a sulfonamide antibiotic. Albon is produced by Pfizer Animal Health and is available as an oral suspension, tablet or bolus. It is used to treat many infections including treatment of respiratory, urinary tract, enteric, and soft tissue infections. It is most frequently used in veterinary medicine. Sulfadimethoxine inhibits bacterial synthesis of folic acid (pteroylglutamic acid) from para-aminobenzoic acid. It is also commonly used for the treatment of coccidiosis in many species.

Reference

1:Comparison of toltrazuril and sulphadimethoxine in the treatment of intestinal coccidiosis in pet rabbits. Redrobe SP, Gakos G, Elliot SC, Saunders R, Martin S, Morgan ER.Vet Rec. 2010 Aug 21;167(8):287-90. doi: 10.1136/vr.c3453. PMID: 20729515 2:Sulphadimethoxine inhibits Phaseolus vulgaris root growth and development of N-fixing nodules. Sartorius M, Riccio A, Cermola M, Casoria P, Patriarca EJ, Taté R.Chemosphere. 2009 Jul;76(3):306-12. doi: 10.1016/j.chemosphere.2009.03.067. Epub 2009 May 6. PMID: 19423149 3:Photodegradation of sulphadimethoxine in water by medium pressure UV lamp. Lester Y, Gozlan I, Avisar D, Mamane H.Water Sci Technol. 2008;58(5):1147-54. doi: 10.2166/wst.2008.668. PMID: 18824816 4:Sulphadimethoxine and Azolla filiculoides Lam.: a model for drug remediation. Forni C, Cascone A, Fiori M, Migliore L.Water Res. 2002 Jul;36(13):3398-403. PMID: 12188140 5:In vitro hepatobiotransformation of sulphadimethoxine in laying hens. Furusawa N.J Vet Med A Physiol Pathol Clin Med. 2001 Apr;48(3):147-52. PMID: 11379388 6:Prevention of pleuropneumonia in pigs by in-feed medication with sulphadimethoxine and sulphamethoxazole in combination with trimethoprim. Mengelers MJ, Kuiper HA, Pijpers A, Verheijden JH, van Miert AS.Vet Q. 2000 Jul;22(3):157-62. PMID: 10952447 7:Simplified determining procedure for routine residue monitoring of sulphamethazine and sulphadimethoxine in milk. Furusawa N.J Chromatogr A. 2000 Nov 17;898(2):185-91. PMID: 11117416 8:Elimination half-lives of sulphadimethoxine and its N4-acetyl metabolite in tissues of laying hens. Furusawa N.Zentralbl Veterinarmed A. 1999 Feb;46(1):59-64. PMID: 10085768 9:Absorbability of sulphamonomethoxine and sulphadimethoxine administered via food of laying hens. Furusawa N.Zentralbl Veterinarmed A. 1998 Jul;45(5):267-9. PMID: 9719757 10:Depletion of dietary sulphamonomethoxine and sulphadimethoxine from various tissues of laying hens. Furusawa N, Mukai T, Ohori H.Br Poult Sci. 1996 May;37(2):435-42. PMID: 8773852