Sulfadiazine

• CAT Number: I004570
• CAS Number: 68-35-9
• Molecular Formula: C10H10N4O2S
• Molecular Weight: 250.28
• Purity: ≥95%
• Target: Antibiotic
• Solubility: DMSO 50 mg/mL; Water <1 mg/mL
• Storage: 2-8°C
• IUPAC Name: 4-amino-N-pyrimidin-2-ylbenzenesulfonamide
• InChI: InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
• InChIKey: SEEPANYCNGTZFQ-UHFFFAOYSA-N
• SMILES: C1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N

Sulfadiazine（Cat No.:I004570） is a sulfonamide antibiotic commonly used in the treatment of bacterial infections. It belongs to the class of drugs known as sulfonamides, which inhibit the growth and reproduction of bacteria by interfering with their ability to synthesize essential metabolites. Sulfadiazine is particularly effective against certain gram-positive and gram-negative bacteria. It is commonly used to treat urinary tract infections, respiratory tract infections, and other bacterial infections. Sulfadiazine works by targeting specific enzymes involved in bacterial metabolism, thereby suppressing their growth and helping to eliminate the infection.

Reference

1:Effects of topical application of silver sulfadiazine cream, triple antimicrobial ointment, or hyperosmolar nanoemulsion on wound healing, bacterial load, and exuberant granulation tissue formation in bandaged full-thickness equine skin wounds. Harmon CCG, Hawkins JF, Li J, Connell S, Miller M, Saenger M, Freeman LJ.Am J Vet Res. 2017 May;78(5):638-646. doi: 10.2460/ajvr.78.5.638. PMID: 28441045 2:Toxicity of sulfadiazine and copper and their interaction to wheat (Triticum aestivum L.) seedlings. Xu Y, Yu W, Ma Q, Zhou H, Jiang C.Ecotoxicol Environ Saf. 2017 Apr 17;142:250-256. doi: 10.1016/j.ecoenv.2017.04.007. [Epub ahead of print] PMID: 28427033 3:Silver sulfadiazine immobilized glass as antimicrobial fillers for dental restorative materials. Srivastava R, Sun Y.Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:524-534. doi: 10.1016/j.msec.2017.02.069. Epub 2017 Feb 17. PMID: 28415495 4:Impact of sulfadiazine on performance and microbial community of a sequencing batch biofilm reactor treating synthetic mariculture wastewater. Li Z, Chang Q, Li S, Gao M, She Z, Guo L, Zhao Y, Jin C, Zheng D, Xu Q.Bioresour Technol. 2017 Jul;235:122-130. doi: 10.1016/j.biortech.2017.03.113. Epub 2017 Mar 22. PMID: 28365339 5:Sulfate radical-based oxidation of antibiotics sulfamethazine, sulfapyridine, sulfadiazine, sulfadimethoxine, and sulfachloropyridazine: Formation of SO2 extrusion products and effects of natural organic matter. Ji Y, Shi Y, Wang L, Lu J, Ferronato C, Chovelon JM.Sci Total Environ. 2017 Sep 1;593-594:704-712. doi: 10.1016/j.scitotenv.2017.03.192. Epub 2017 Mar 28. PMID: 28363182 6:Technetium-99m-Labeled Sulfadiazine: a Targeting Radiopharmaceutical for Scintigraphic Imaging of Infectious Foci Due To Escherichia coli in Mouse and Rabbit Models. Ahmed MT, Naqvi SA, Rasheed R, Zahoor AF, Usman M, Hussain Z.Appl Biochem Biotechnol. 2017 Mar 11. doi: 10.1007/s12010-017-2451-2. [Epub ahead of print] PMID: 28285355 7:Heterogeneity of mast cells and expression of Annexin A1 protein in a second degree burn model with silver sulfadiazine treatment. Souza HR, de Azevedo LR, Possebon L, Costa SS, Iyomasa-Pilon MM, Oliani SM, Girol AP.PLoS One. 2017 Mar 9;12(3):e0173417. doi: 10.1371/journal.pone.0173417. eCollection 2017. PMID: 28278234 Free PMC Article8:Environmental behavior of sulfadiazine, sulfamethazine, and their metabolites. Biošić M, Mitrevski M, Babić S.Environ Sci Pollut Res Int. 2017 Apr;24(10):9802-9812. doi: 10.1007/s11356-017-8639-8. Epub 2017 Mar 3. PMID: 28258427 9:Partial-thickness burn wounds healing by topical treatment: A randomized controlled comparison between silver sulfadiazine and centiderm. Saeidinia A, Keihanian F, Lashkari AP, Lahiji HG, Mobayyen M, Heidarzade A, Golchai J.Medicine (Baltimore). 2017 Mar;96(9):e6168. doi: 10.1097/MD.0000000000006168. PMID: 28248871 Free PMC Article10:Experimental burns: Comparison between silver sulfadiazine and photobiomodulation. Gomes MT, Campos GR, Piccolo N, França CM, Guedes GH, Lopes F, Belotto RA, Pavani C, Lima RD, Silva DF.Rev Assoc Med Bras (1992). 2017 Jan 1;63(1):29-34. doi: 10.1590/1806-9282.63.01.29. PMID: 28225874 Free Article