Stibogluconate sodium

• CAT Number: I002038
• CAS Number: 16037-91-5
• Molecular Formula: C12H17O17Sb2 • 3Na [9H2O]
• Molecular Weight: 907.9
• Purity: ≥95%
• Synonyms: Antimony Sodium Gluconate
• Target: target: SHP-1, SHP-2, PTP1B.[1]
• Storage: -20°C
• InChIKey: XGOCPLVXEKPVLV-UZVLBLASSA-L

Stibogluconate sodium is is a potent inhibitor of PTPases Src homology PTPase1 (SHP-1), SHP-2, and PTP1B, inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10 μg/ml, 100 μg/ml respectively.target: SHP-1, SHP-2, PTP1B.[1]In vitro: Stibogluconate sodium inhibits protein tyrosine phosphatases. Stibogluconate sodium targets the SHP-1 PTPase catalytic domain and forms stable complexes with the phosphatase. Stibogluconate sodium induces tyrosine phosphorylation of cellular proteins and augments IL-3-induces Jak2/Stat5 phosphorylation in Baf3 cells. Stibogluconate sodium augments IL-3-induced cell proliferation of Baf3 cells. [1]In vivo: SSG induces 61% growth inhibition of Renca tumors in BALB/c mice coincident with an increase (2-fold) in tumorinfiltrating macrophages (M). [2]

Reference

[1]. Pathak MK et al. Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines. J Immunol. 2001 Sep 15;167(6):3391-7.
[2]. Keke Fan et al. Sodium Stibogluconate Interacts with IL-2 in Anti-Renca Tumor Action via a T Cell-Dependent Mechanism in Connection with Induction of Tumor-Infiltrating Macrophages. The journal of immunology. 2016 Sep 27.