SRT2183

• CAT Number: I009583
• CAS Number: 1001908-89-9
• Molecular Formula: C27H24N4O2S
• Molecular Weight: 468.57
• Purity: ≥95%
• Solubility: Soluble in DMSO, not in water
• Storage: Store at -20°C
• IUPAC Name: N-[2-[3-[[(3R)-3-hydroxypyrrolidin-1-yl]methyl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]naphthalene-2-carboxamide
• InChI: InChI=1S/C27H24N4O2S/c32-22-11-12-30(15-22)14-21-17-34-27-29-25(16-31(21)27)23-7-3-4-8-24(23)28-26(33)20-10-9-18-5-1-2-6-19(18)13-20/h1-10,13,16-17,22,32H,11-12,14-15H2,(H,28,33)/t22-/m1/s1
• InChIKey: MUFSINOSQBMSLE-JOCHJYFZSA-N
• SMILES: C1CN(CC1O)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=CC6=CC=CC=C6C=C5

SRT2183 (Cat No.:I009583) is a potent activator of SIRT1, a protein involved in cellular processes such as metabolism and aging. By activating SIRT1, SRT2183 enhances its enzymatic activity, resulting in various beneficial effects. These include improved mitochondrial function, increased insulin sensitivity, and potential protection against age-related diseases. SRT2183 has been investigated for its therapeutic potential in metabolic disorders, neurodegenerative diseases, and age-related conditions. Its ability to modulate SIRT1 activity makes it an intriguing compound for research into mechanisms of cellular function and potential therapeutic interventions.

Reference

1:The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells. Gurt I, Artsi H, Cohen-Kfir E, Hamdani G, Ben-Shalom G, Feinstein B, El-Haj M, Dresner-Pollak R.PLoS One. 2015 Jul 30;10(7):e0134391. doi: 10.1371/journal.pone.0134391. eCollection 2015. PMID: 26226624 Free PMC Article2:SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183. Huber JL, McBurney MW, Distefano PS, McDonagh T.Future Med Chem. 2010 Dec;2(12):1751-9. doi: 10.4155/fmc.10.257. PMID: 21428798 3:SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, Garofalo RS, Griffith D, Griffor M, Loulakis P, Pabst B, Qiu X, Stockman B, Thanabal V, Varghese A, Ward J, Withka J, Ahn K.J Biol Chem. 2010 Mar 12;285(11):8340-51. doi: 10.1074/jbc.M109.088682. Epub 2010 Jan 8. PMID: 20061378 Free PMC Article