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SIS17

SIS17

  • CAT Number: I018039
  • CAS Number: 2374313-54-7
  • Molecular Formula: C₂₁H₃₈N₂OS
  • Molecular Weight: 366.6
  • Purity: ≥95%
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SIS17(CAT: I018039), with the chemical name (E)-N-hydroxy-3-(3-methyl-2-oxo-1,3,2λ⁵-benzothiazol-4-yl)acrylamide, is a potent inhibitor of mammalian histone deacetylase 11 (HDAC 11) with an IC50 value of 0.83 μM. It specifically targets HDAC11 without inhibiting other HDAC enzymes. SIS17 is known to inhibit the demyristoylation of HDAC11 substrate serine hydroxymethyl transferase 2 (SHMT2).

Catalog Number I018039
CAS Number 2374313-54-7
Molecular Formula

C₂₁H₃₈N₂OS

Purity 95%
Reference

[1]. Son SI, et al. Activity-Guided Design of HDAC11-Specific Inhibitors. ACS Chem Biol. 2019 Jul 19;14(7):1393-1397.

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