SC-435

• CAT Number: I036085
• CAS Number: 289037-67-8
• Molecular Formula: C37H59N3O7S2
• Molecular Weight: 722.01
• Purity: ≥95%
• Synonyms: (4R,5R)-5-[4-[4-(4-aza-1-azoniabicyclo[2.2.2]octan-1-yl)butoxy]phenyl]-3,3-dibutyl-7-(dimethylamino)-1,1-dioxo-4,5-dihydro-2H-1λ6-benzothiepin-4-ol;methanesulfonate
• IUPAC Name: (4R,5R)-5-[4-[4-(4-aza-1-azoniabicyclo[2.2.2]octan-1-yl)butoxy]phenyl]-3,3-dibutyl-7-(dimethylamino)-1,1-dioxo-4,5-dihydro-2H-1lambda6-benzothiepin-4-ol;methanesulfonate
• InChI: InChI=1S/C36H56N3O4S.CH4O3S/c1-5-7-17-36(18-8-6-2)28-44(41,42)33-16-13-30(37(3)4)27-32(33)34(35(36)40)29-11-14-31(15-12-29)43-26-10-9-22-39-23-19-38(20-24-39)21-25-39;1-5(2,3)4/h11-16,27,34-35,40H,5-10,17-26,28H2,1-4H3;1H3,(H,2,3,4)/q+1;/p-1/t34-,35-;/m1./s1
• InChIKey: VRHOEJBXKXQDQB-SWIBWIMJSA-M
• SMILES: CCCCC1(CS(=O)(=O)C2=C(C=C(C=C2)N(C)C)[C@H]([C@H]1O)C3=CC=C(C=C3)OCCCC[N+]45CCN(CC4)CC5)CCCC.CS(=O)(=O)[O-]

SC-435（Cat No.:I036085）is a selective and potent inhibitor of the intestinal sterol transporter NPC1L1 (Niemann-Pick C1-Like 1), a protein crucial for cholesterol absorption in the small intestine. By blocking NPC1L1, SC-435 effectively reduces dietary and biliary cholesterol uptake, leading to lower plasma cholesterol levels. It is widely used in cardiovascular and metabolic disease research to study lipid metabolism, atherosclerosis, and hypercholesterolemia. SC-435 serves as a valuable tool for evaluating NPC1L1 function, comparing with agents like ezetimibe, and exploring combination therapies targeting cholesterol biosynthesis and absorption pathways in preclinical models.