Betahistine HCl

• CAT Number: I004171
• CAS Number: 5579-84-0 (HCl)
• Molecular Formula: C8H14Cl2N2
• Molecular Weight: 209.114
• Purity: ≥95%
• Target: H1 receptor agonist
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term or -20 °C for long term
• IUPAC Name: N-methyl-2-pyridin-2-ylethanamine;dihydrochloride
• InChI: InChI=1S/C8H12N2.2ClH/c1-9-7-5-8-4-2-3-6-10-8;;/h2-4,6,9H,5,7H2,1H3;2*1H
• InChIKey: XVDFMHARQUBJRE-UHFFFAOYSA-N
• SMILES: CNCCC1=CC=CC=N1.Cl.Cl

Betahistine hydrochloride (Cat. No: I004171), also known as anti-glare, betahistine, is a histamine H1 receptor agonist, belonging to histamine vasodilator drugs, mainly used in the treatment of Meniere’s disease.

Reference

1:Long-term evaluation of the treatment of Menière/’s disease with betahistine HCl. Bertrand RA.Adv Otorhinolaryngol. 1982;28:104-10. PMID: 7113814 2:Increased coronary collateral blood flow. A possible mechanism of action for betahistine-HCl. Terracio L, Kubicek WG.Acta Anat (Basel). 1979;103(4):461-7. PMID: 442956 3:Modification of the size of developing infarcts in the ligated dog heart by betahistine-HCL. Terracio L, Kubicek WG.Acta Anat (Basel). 1978;101(4):372-9. PMID: 665141 4:Betahistine HCL antagonism upon neural influence on microcirculation. Baez S, Gootman PM, Feldman SM, Orkin LR.Bibl Anat. 1973;12:437-42. No abstract available. PMID: 4208230 5:Méniére/’s disease: subjective and objective evaluation of medical treatment with betahistine HCl. Bertrand RA.Acta Otolaryngol Suppl. 1972;305:48-69. No abstract available. PMID: 4353750 6:Effects of betahistine HCl, nicotinic acid, and histamine on basilar blood flow in anesthetized dogs. Anderson WD, Kubicek WG.Stroke. 1971 Jul-Aug;2(4):409-15. No abstract available. PMID: 5000331 Free Article7:Modification of the vestibular function with betahistine HCl. Bertrand RA.Laryngoscope. 1971 Jun;81(6):889-98. No abstract available. PMID: 4997046