LM22A-4

• CAT Number: I003394
• CAS Number: 37988-18-4
• Molecular Formula: C15H21N3O6
• Molecular Weight: 339.348
• Purity: ≥95%
• Target: Trk
• Solubility: DMSO: ≥ 29 mg/mL
• Storage: Store at +4C
• IUPAC Name: 1-N,3-N,5-N-tris(2-hydroxyethyl)benzene-1,3,5-tricarboxamide
• InChI: InChI=1S/C15H21N3O6/c19-4-1-16-13(22)10-7-11(14(23)17-2-5-20)9-12(8-10)15(24)18-3-6-21/h7-9,19-21H,1-6H2,(H,16,22)(H,17,23)(H,18,24)
• InChIKey: RGWJKANXFYJKHN-UHFFFAOYSA-N
• SMILES: C1=C(C=C(C=C1C(=O)NCCO)C(=O)NCCO)C(=O)NCCO

LM22A-4 is a specific agonist of tyrosine kinase receptor B.IC50:Target: Trk Receptor BIn vitro: LM22A-4 significantly up-regulates OPN and ALPase mRNA expression in a dose-dependent manner and OC mRNA level is significantly increased by 5 μM of LM22A-4. LM22A-4 significantly increases OPN, ALPase and OC mRNA expression in a time-dependent manner. LM22A-4 stimulated OPN and OC mRNA expression in HCEM cells cultured with mineralizing media[2].In vivo: LM22A-4 (10 mg/kg, i.p.) significantly reduces the degree of tissue injury and apoptosis (TUNEL staining and caspase-3 and Bcl-2 expression) compared with vehicle treated group. LM22A-4 also significantly ameliorates the recovery of limb function. LM22A-4 (10 mg/kg) treatment results in a significant increase in neuron number. LM22A-4 administration (10 mg/kg) significantly improves the neurological scores compared with those of the solvent-treated animals[1].

Reference

[1]. Yu G, et al. Protective effects of LM22A-4 on injured spinal cord nerves. Int J Clin Exp Pathol. 2015 Jun 1;8(6):6526-32. eCollection 2015.
[2]. Kajiya M, et al. BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade. Int Immunopharmacol. 2014 Apr;19(2):245-52.